Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CBLN3 | ENSG00000139899 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| SERPINA4 | ENSG00000100665 | 0.00 | 0.51 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 2.26 | 2.79 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 3.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LIPC | ENSG00000166035 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| TPSD1 | ENSG00000095917 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 0.43 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GALNS | ENSG00000141012 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.00 | 3.08 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| OR6J1 | ENSG00000255804 | |||||||||||||||||||||||||||||||||
| PPY | ENSG00000108849 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| WFIKKN2 | ENSG00000173714 | 1.11 | 1.02 | 0.21 | 0.73 | 2.86 | 0.65 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.59 | 0.56 | 1.51 | 1.93 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 2.61 | 0.81 | 0.00 | 0.00 | 0.83 | 0.22 | 0.00 | 0.00 |
| GPR33 | ENSG00000214943 | |||||||||||||||||||||||||||||||||
| PRTN3 | ENSG00000196415 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1D5 | ENSG00000262628 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| LIPE | ENSG00000079435 | 2.22 | 2.29 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 1.20 | 0.00 | 1.36 | 0.71 | 0.00 | 0.39 | 0.56 | 0.75 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.37 | 0.00 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| IGFL1 | ENSG00000188293 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DKKL1 | ENSG00000104901 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NAPSA | ENSG00000131400 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.00 | 0.00 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GPBAR1 | ENSG00000179921 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.56 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR2V1 | ENSG00000185372 | |||||||||||||||||||||||||||||||||
| OPN1MW | ENSG00000268221 | |||||||||||||||||||||||||||||||||
| FKBP7 | ENSG00000079150 | 0.00 | 0.25 | 0.10 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR4C5 | ENSG00000176540 |
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