Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SFTPA2 | ENSG00000185303 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 1.50 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SFTPA1 | ENSG00000122852 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LIPF | ENSG00000182333 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LGI1 | ENSG00000108231 | 1.11 | 1.02 | 0.52 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.28 | 1.32 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| WNT8B | ENSG00000075290 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KAZALD1 | ENSG00000107821 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR51H1 | ENSG00000176904 | |||||||||||||||||||||||||||||||||
| HABP2 | ENSG00000148702 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.94 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CPXM2 | ENSG00000121898 | 1.11 | 1.27 | 0.31 | 1.09 | 0.00 | 1.94 | 0.00 | 2.21 | 0.52 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 3.77 | 1.07 | 0.00 | 0.00 | 1.72 | 0.00 | 0.41 | 1.56 | 0.00 | 7.11 | 2.71 | 0.00 | 0.00 | 0.00 | 4.21 | 0.00 | 0.00 |
| SCUBE2 | ENSG00000175356 | 1.11 | 1.27 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 1.32 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 3.25 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| CALCA | ENSG00000110680 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR56A5 | ENSG00000188691 | |||||||||||||||||||||||||||||||||
| OR8U1 | ENSG00000172199 | 0.00 | 0.51 | 0.31 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 6.03 | 3.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 2.34 | 0.43 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR10G6 | ENSG00000198674 | |||||||||||||||||||||||||||||||||
| UCP3 | ENSG00000175564 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR2AP1 | ENSG00000179615 | |||||||||||||||||||||||||||||||||
| SPX | ENSG00000134548 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| IL22 | ENSG00000127318 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IL31 | ENSG00000204671 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RNASE6 | ENSG00000169413 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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