Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CTRB1 | ENSG00000168925 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| USP6 | ENSG00000129204 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 0.65 | 2.70 | 1.10 | 1.29 | 1.39 | 0.00 | 0.00 | 0.36 | 1.47 | 0.59 | 0.83 | 2.64 | 2.36 | 0.00 | 1.72 | 0.00 | 0.00 | 0.61 | 0.00 | 1.29 | 7.11 | 0.54 | 0.00 | 0.41 | 0.00 | 2.66 | 0.00 | 0.00 |
| WNT3 | ENSG00000108379 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 0.80 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.23 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAN2B1 | ENSG00000104774 | 0.00 | 1.78 | 0.41 | 2.19 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 1.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 0.94 | 0.86 | 0.00 | 0.98 | 0.57 | 0.56 | 0.41 | 1.56 | 0.00 | 1.42 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| MUC3A | ENSG00000169894 | 0.00 | 2.54 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 1.29 | 1.39 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.00 | 2.26 | 4.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 6.40 | 1.08 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| IL4I1 | ENSG00000104951 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| SVOP | ENSG00000166111 | 0.00 | 0.00 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.21 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| STK17B | ENSG00000081320 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| WFDC11 | ENSG00000180083 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LTF | ENSG00000012223 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.28 | 1.32 | 0.64 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 4.27 | 1.36 | 0.69 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| GSK3B | ENSG00000082701 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HGFAC | ENSG00000109758 | 1.11 | 0.76 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| NAAA | ENSG00000138744 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ARSJ | ENSG00000180801 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 1.13 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.37 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 1.82 | 1.25 |
| TSLP | ENSG00000145777 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PIM1 | ENSG00000137193 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 21.62 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SGK1 | ENSG00000118515 | 1.11 | 1.02 | 0.41 | 0.00 | 0.00 | 0.65 | 5.41 | 1.10 | 0.52 | 0.40 | 0.00 | 0.81 | 1.42 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.83 | 2.88 | 0.00 | 0.00 |
| HGF | ENSG00000019991 | 0.00 | 2.54 | 0.31 | 1.46 | 0.00 | 1.94 | 0.00 | 1.10 | 0.26 | 1.99 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 2.50 | 6.40 | 6.22 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 1.56 | 0.43 | 5.69 | 3.52 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| CDK14 | ENSG00000058091 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 1.94 | 2.70 | 0.55 | 0.00 | 1.00 | 0.00 | 0.54 | 0.00 | 1.47 | 0.00 | 0.56 | 0.94 | 2.15 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 1.63 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| WNT16 | ENSG00000002745 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 1.13 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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