Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| IGHM | ENSG00000211899 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 1.61 | 21.62 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 1.69 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 3.08 | 2.44 | 0.69 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| SHH | ENSG00000164690 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ENHO | ENSG00000168913 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KCND1 | ENSG00000102057 | 1.11 | 0.51 | 0.52 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| PAPPA2 | ENSG00000116183 | 3.33 | 4.58 | 2.17 | 1.82 | 0.00 | 6.45 | 0.00 | 6.08 | 1.80 | 8.57 | 0.00 | 0.54 | 0.71 | 0.74 | 0.78 | 1.11 | 15.44 | 16.74 | 2.47 | 1.72 | 2.30 | 0.56 | 0.81 | 3.91 | 1.29 | 19.43 | 5.42 | 0.00 | 0.00 | 0.00 | 4.43 | 1.82 | 1.25 |
| IL19 | ENSG00000142224 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 1.56 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MARK1 | ENSG00000116141 | 1.11 | 2.04 | 0.93 | 1.82 | 0.00 | 2.26 | 2.70 | 2.21 | 0.52 | 1.59 | 0.00 | 1.36 | 0.00 | 0.74 | 0.20 | 0.28 | 3.58 | 1.93 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 3.13 | 0.86 | 4.03 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AGT | ENSG00000135744 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| PRKCQ | ENSG00000065675 | 1.11 | 1.78 | 0.72 | 0.36 | 2.86 | 1.29 | 0.00 | 1.66 | 0.26 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.11 | 1.32 | 2.15 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 4.03 | 2.44 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| COMTD1 | ENSG00000165644 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MMP17 | ENSG00000198598 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 1.69 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 1.90 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| GALC | ENSG00000054983 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 1.51 | 2.36 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| SERPINA10 | ENSG00000140093 | 1.11 | 0.76 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 1.29 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 0.00 | 0.43 | 5.92 | 1.63 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| AKT1 | ENSG00000142208 | 0.00 | 0.76 | 2.58 | 2.19 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 1.02 | 0.83 | 2.66 | 0.00 | 0.00 |
| EPB42 | ENSG00000166947 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.56 | 1.32 | 1.72 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CNTNAP3B | ENSG00000154529 | 0.00 | 0.76 | 0.10 | 1.09 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 2.26 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IGFALS | ENSG00000099769 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| TXNDC11 | ENSG00000153066 | 0.00 | 1.53 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PLA2G10 | ENSG00000069764 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CYLD | ENSG00000083799 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 2.21 | 0.52 | 2.19 | 1.54 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 1.32 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 1.63 | 0.00 | 0.20 | 1.65 | 1.55 | 0.00 | 1.25 |
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