Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BMP5 | ENSG00000112175 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 1.29 | 2.70 | 0.55 | 1.03 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.11 | 1.13 | 3.00 | 0.00 | 0.49 | 1.15 | 0.00 | 0.41 | 0.00 | 0.00 | 7.58 | 1.08 | 0.00 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| NOS3 | ENSG00000164867 | 4.44 | 3.05 | 0.62 | 1.09 | 2.86 | 0.65 | 0.00 | 1.66 | 1.03 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 1.94 | 1.13 | 1.29 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 1.56 | 0.43 | 4.74 | 1.08 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| SLC22A15 | ENSG00000163393 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC45A3 | ENSG00000158715 | 0.00 | 0.51 | 0.41 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CACNB2 | ENSG00000165995 | 0.00 | 1.53 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 3.01 | 2.36 | 0.00 | 0.25 | 0.57 | 0.56 | 0.41 | 0.78 | 0.00 | 2.37 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| USP8 | ENSG00000138592 | 0.00 | 3.05 | 0.52 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.59 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.83 | 1.88 | 1.07 | 1.23 | 0.49 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ATP5A1 | ENSG00000152234 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.56 | 0.56 | 1.07 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NALCN | ENSG00000102452 | 0.00 | 4.58 | 1.34 | 1.82 | 0.00 | 6.45 | 0.00 | 3.31 | 1.29 | 5.38 | 0.00 | 2.44 | 1.07 | 0.00 | 0.20 | 1.39 | 12.62 | 8.15 | 1.23 | 2.21 | 0.57 | 0.00 | 1.83 | 3.91 | 0.86 | 6.40 | 6.50 | 0.00 | 0.20 | 0.83 | 3.99 | 0.00 | 0.00 |
| KLK3 | ENSG00000142515 | 0.00 | 0.00 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 1.13 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.81 | 0.78 | 0.43 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LCTL | ENSG00000188501 | 1.11 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| KLK2 | ENSG00000167751 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| KLK13 | ENSG00000167759 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.29 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TNFRSF12A | ENSG00000006327 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ABCC12 | ENSG00000140798 | 0.00 | 2.80 | 0.83 | 1.09 | 0.00 | 2.58 | 0.00 | 2.21 | 0.00 | 1.59 | 0.00 | 0.81 | 1.07 | 0.74 | 0.20 | 0.83 | 2.64 | 5.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 1.56 | 0.86 | 5.45 | 2.17 | 0.00 | 0.00 | 0.83 | 3.77 | 0.00 | 0.00 |
| SLC38A8 | ENSG00000166558 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 0.00 | 0.25 | 1.15 | 0.00 | 0.41 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC16A13 | ENSG00000174327 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| DHRS7B | ENSG00000109016 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| LMTK3 | ENSG00000142235 | 0.00 | 1.78 | 0.21 | 2.19 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 1.00 | 1.54 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 0.19 | 0.86 | 1.23 | 0.49 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| FUT2 | ENSG00000176920 | 0.00 | 1.27 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC16A14 | ENSG00000163053 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.74 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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