Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| HVCN1 | ENSG00000122986 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| UGGT1 | ENSG00000136731 | 0.00 | 2.29 | 0.41 | 0.36 | 2.86 | 0.97 | 0.00 | 2.21 | 2.06 | 1.00 | 1.54 | 0.81 | 0.36 | 0.00 | 0.59 | 0.28 | 1.69 | 2.15 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| SPNS2 | ENSG00000183018 | 1.11 | 0.00 | 0.00 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| KLK5 | ENSG00000167754 | 0.00 | 0.51 | 0.10 | 0.00 | 2.86 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 1.13 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| VIP | ENSG00000146469 | 1.11 | 0.00 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.56 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| LILRA4 | ENSG00000239961 | 0.00 | 0.76 | 0.52 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 2.64 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| SLC4A5 | ENSG00000188687 | 0.00 | 1.53 | 0.83 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 1.03 | 1.39 | 3.08 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 2.26 | 1.72 | 1.23 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.08 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| TGFB2 | ENSG00000092969 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 0.64 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| COMT | ENSG00000093010 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PDE2A | ENSG00000186642 | 1.11 | 0.25 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.54 | 0.71 | 0.00 | 0.78 | 0.00 | 1.69 | 1.07 | 0.00 | 1.72 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.37 | 2.17 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| KLK11 | ENSG00000167757 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.18 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KLK14 | ENSG00000129437 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.83 | 0.22 | 0.00 | 0.00 |
| TNFSF10 | ENSG00000121858 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 1.07 | 2.21 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COL25A1 | ENSG00000188517 | 2.22 | 2.04 | 0.52 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.20 | 1.54 | 0.00 | 0.36 | 1.47 | 0.39 | 0.28 | 4.33 | 2.36 | 0.00 | 0.49 | 1.15 | 0.00 | 0.20 | 0.00 | 0.43 | 3.79 | 0.27 | 0.00 | 0.00 | 0.83 | 2.66 | 0.00 | 1.25 |
| SFTPB | ENSG00000168878 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| DST | ENSG00000151914 | 6.67 | 7.12 | 2.27 | 6.20 | 0.00 | 3.87 | 5.41 | 4.42 | 2.84 | 6.57 | 3.08 | 3.79 | 2.85 | 1.47 | 0.98 | 3.06 | 9.60 | 6.87 | 2.47 | 4.90 | 1.72 | 0.00 | 0.61 | 6.25 | 1.72 | 7.35 | 5.42 | 1.39 | 0.41 | 0.00 | 8.65 | 3.64 | 0.00 |
| IGLL5 | ENSG00000254709 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.32 | 32.43 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TAS2R5 | ENSG00000127366 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GDF9 | ENSG00000164404 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 1.29 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TULP1 | ENSG00000112041 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.28 | 0.56 | 0.86 | 1.23 | 1.23 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 2.61 | 0.81 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
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