Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CD247 | ENSG00000198821 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| FCAMR | ENSG00000162897 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| OR8B2 | ENSG00000204293 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.69 | 3.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TAS2R10 | ENSG00000121318 | 0.00 | 0.00 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TAS2R43 | ENSG00000255374 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.00 | 0.54 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DIO3 | ENSG00000197406 | 1.11 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.50 | 0.00 | 1.23 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| VAMP2 | ENSG00000220205 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GPR179 | ENSG00000277399 | |||||||||||||||||||||||||||||||||
| CD300LD | ENSG00000204345 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC30A2 | ENSG00000158014 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| C1orf27 | ENSG00000157181 | 0.00 | 0.25 | 0.00 | 1.09 | 0.00 | 0.32 | 2.70 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CAMK2G | ENSG00000148660 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RYR3 | ENSG00000198838 | 3.33 | 9.67 | 3.41 | 4.38 | 2.86 | 9.35 | 0.00 | 8.29 | 4.38 | 6.18 | 0.00 | 2.98 | 2.14 | 1.47 | 1.37 | 5.28 | 15.44 | 18.88 | 2.47 | 2.21 | 2.87 | 0.56 | 2.04 | 7.03 | 1.72 | 13.74 | 7.05 | 1.39 | 0.20 | 0.00 | 9.09 | 0.00 | 0.00 |
| TMEM256-PLSCR3 | ENSG00000187838 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LRIT2 | ENSG00000204033 | 1.11 | 0.76 | 0.31 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 1.47 | 0.20 | 0.00 | 2.26 | 2.36 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 1.63 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLSCR4 | ENSG00000114698 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 1.79 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| ELOVL6 | ENSG00000170522 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC22A25 | ENSG00000196600 | 0.00 | 0.76 | 0.62 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.77 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 1.32 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 4.27 | 0.81 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| CAMK2B | ENSG00000058404 | 0.00 | 1.02 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.28 | 2.64 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 1.18 | 0.81 | 0.69 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| KLK8 | ENSG00000129455 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 2.07 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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