Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TPCN1 | ENSG00000186815 | 0.00 | 1.27 | 0.72 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.28 | 0.94 | 1.50 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 1.36 | 0.00 | 0.00 | 0.83 | 2.44 | 0.00 | 2.50 |
| TMED1 | ENSG00000099203 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SCN3A | ENSG00000153253 | 0.00 | 4.07 | 1.24 | 2.55 | 0.00 | 3.87 | 5.41 | 3.87 | 1.29 | 3.59 | 0.00 | 1.08 | 0.00 | 1.47 | 1.18 | 1.67 | 8.29 | 5.36 | 0.00 | 2.94 | 1.15 | 0.00 | 0.20 | 2.34 | 0.86 | 10.66 | 5.42 | 0.00 | 0.41 | 0.00 | 3.10 | 3.64 | 0.00 |
| SCN10A | ENSG00000185313 | 0.00 | 3.31 | 1.65 | 1.09 | 0.00 | 2.26 | 0.00 | 2.21 | 2.32 | 2.19 | 0.00 | 0.27 | 1.07 | 0.00 | 0.98 | 2.22 | 7.16 | 6.22 | 0.00 | 1.72 | 0.00 | 0.56 | 1.02 | 3.13 | 1.29 | 20.38 | 6.50 | 0.00 | 0.20 | 0.00 | 4.88 | 1.82 | 0.00 |
| SCN11A | ENSG00000168356 | 1.11 | 2.80 | 1.45 | 2.19 | 0.00 | 2.90 | 0.00 | 2.76 | 1.80 | 2.19 | 0.00 | 0.54 | 1.78 | 0.00 | 0.78 | 1.11 | 4.90 | 5.36 | 2.47 | 1.23 | 0.57 | 0.00 | 1.02 | 3.91 | 0.43 | 20.62 | 3.79 | 0.00 | 0.20 | 0.00 | 3.55 | 1.82 | 1.25 |
| RHD | ENSG00000187010 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SLC30A10 | ENSG00000196660 | 0.00 | 0.25 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 2.45 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| SLC39A12 | ENSG00000148482 | 0.00 | 1.78 | 0.83 | 0.00 | 0.00 | 0.32 | 0.00 | 2.76 | 0.00 | 2.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.94 | 6.21 | 6.65 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.55 | 2.17 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC29A3 | ENSG00000198246 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| KCNA4 | ENSG00000182255 | 0.00 | 0.76 | 0.93 | 1.09 | 0.00 | 1.94 | 0.00 | 1.10 | 1.29 | 1.59 | 0.00 | 0.54 | 0.36 | 0.74 | 0.39 | 1.39 | 4.90 | 5.79 | 0.00 | 1.23 | 1.72 | 0.00 | 0.20 | 2.34 | 0.43 | 1.90 | 2.44 | 0.69 | 0.20 | 0.00 | 4.21 | 1.82 | 0.00 |
| TRPV1 | ENSG00000196689 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SPPL2C | ENSG00000185294 | 0.00 | 1.02 | 0.21 | 0.00 | 2.86 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.28 | 1.88 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 2.84 | 1.08 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| KCNH8 | ENSG00000183960 | 1.11 | 3.31 | 0.62 | 1.09 | 0.00 | 2.26 | 2.70 | 1.66 | 0.77 | 1.99 | 0.00 | 0.81 | 0.71 | 0.74 | 0.39 | 1.11 | 5.46 | 4.72 | 0.00 | 1.47 | 0.00 | 0.00 | 0.41 | 3.13 | 1.72 | 5.45 | 3.79 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| SLC35A5 | ENSG00000138459 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MGST2 | ENSG00000085871 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| KCNN2 | ENSG00000080709 | 0.00 | 1.02 | 0.52 | 1.46 | 0.00 | 1.29 | 0.00 | 3.31 | 0.00 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.59 | 0.83 | 2.45 | 3.86 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 2.44 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| KCNS2 | ENSG00000156486 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.54 | 1.07 | 0.74 | 0.20 | 0.56 | 3.20 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 1.66 | 0.54 | 0.00 | 0.41 | 0.00 | 1.77 | 1.82 | 0.00 |
| SLC30A8 | ENSG00000164756 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 1.03 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.39 | 1.13 | 2.36 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 4.27 | 1.36 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| OR5T1 | ENSG00000181698 | 0.00 | 2.04 | 0.62 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 2.45 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 4.03 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2H2 | ENSG00000204657 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 1.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
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