Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BMP2 | ENSG00000125845 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.32 | 5.41 | 0.00 | 0.77 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| DEFB116 | ENSG00000215545 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LBP | ENSG00000129988 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 1.03 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.00 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 1.08 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| HRG | ENSG00000113905 | 2.22 | 1.53 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.40 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 1.69 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 3.79 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ADIPOQ | ENSG00000181092 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IL4 | ENSG00000113520 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LY86 | ENSG00000112799 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IL17A | ENSG00000112115 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SFRP4 | ENSG00000106483 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 1.79 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| DEFB104A | ENSG00000176782 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NRD1 | ENSG00000078618 | 0.00 | 1.78 | 0.72 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 2.39 | 0.00 | 1.08 | 1.07 | 0.00 | 0.39 | 1.67 | 1.32 | 2.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 1.29 | 0.95 | 1.08 | 0.00 | 0.00 | 0.83 | 2.22 | 3.64 | 0.00 |
| ADAMTS7 | ENSG00000136378 | 1.11 | 1.27 | 0.83 | 1.46 | 0.00 | 2.90 | 2.70 | 1.66 | 0.52 | 1.79 | 1.54 | 1.08 | 1.07 | 0.00 | 0.00 | 1.39 | 2.64 | 3.43 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 5.92 | 1.36 | 0.00 | 0.61 | 0.83 | 3.33 | 1.82 | 0.00 |
| BSPH1 | ENSG00000188334 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PDGFB | ENSG00000100311 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| SPARC | ENSG00000113140 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 1.51 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MCOLN3 | ENSG00000055732 | 0.00 | 1.02 | 0.52 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 1.80 | 0.80 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.28 | 1.32 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| KCNT2 | ENSG00000162687 | 1.11 | 1.53 | 1.24 | 1.82 | 2.86 | 3.23 | 2.70 | 5.52 | 0.52 | 4.58 | 0.00 | 0.81 | 1.42 | 0.00 | 0.98 | 1.39 | 8.29 | 5.36 | 0.00 | 0.98 | 0.57 | 0.56 | 1.02 | 3.91 | 0.86 | 11.37 | 5.69 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| KCNH1 | ENSG00000143473 | 2.22 | 1.53 | 0.72 | 1.46 | 0.00 | 1.94 | 2.70 | 3.31 | 1.80 | 1.99 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 1.39 | 5.46 | 5.36 | 1.23 | 2.21 | 0.57 | 0.00 | 0.20 | 1.56 | 0.86 | 5.45 | 2.44 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| SYT15 | ENSG00000204176 | 0.00 | 1.53 | 0.31 | 0.73 | 0.00 | 1.29 | 2.70 | 0.00 | 0.52 | 0.40 | 0.00 | 1.08 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| SCN8A | ENSG00000196876 | 3.33 | 2.04 | 1.34 | 2.92 | 5.71 | 1.94 | 0.00 | 1.66 | 1.03 | 2.19 | 0.00 | 0.27 | 1.07 | 1.47 | 0.20 | 0.28 | 3.39 | 3.43 | 0.00 | 2.45 | 0.57 | 0.00 | 0.41 | 1.56 | 0.86 | 4.50 | 1.36 | 0.00 | 0.20 | 0.00 | 2.44 | 1.82 | 0.00 |
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