Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TUBB4A | ENSG00000104833 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 1.29 | 2.70 | 0.00 | 1.03 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.56 | 2.45 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| CST8 | ENSG00000125815 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TSPEAR | ENSG00000175894 | 0.00 | 1.27 | 0.62 | 1.82 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.80 | 1.54 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 1.69 | 1.93 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 2.13 | 0.00 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| KLKB1 | ENSG00000164344 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 1.79 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.94 | 1.72 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.86 | 3.55 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| F11 | ENSG00000088926 | 0.00 | 2.54 | 0.00 | 1.09 | 0.00 | 0.65 | 2.70 | 1.10 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 3.08 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TUBB | ENSG00000196230 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.55 | 0.26 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SERPINE1 | ENSG00000106366 | 1.11 | 1.02 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 2.26 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| BMX | ENSG00000102010 | 0.00 | 1.27 | 0.52 | 1.09 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 0.75 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| ENOX2 | ENSG00000165675 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 2.64 | 2.15 | 1.23 | 1.23 | 0.00 | 1.12 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| ANGPTL3 | ENSG00000132855 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| DEFB108B | ENSG00000184276 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LGALS3 | ENSG00000131981 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IGHG4 | ENSG00000211892 | 2.22 | 1.53 | 0.41 | 0.00 | 0.00 | 0.32 | 8.11 | 1.66 | 0.00 | 1.20 | 0.00 | 0.81 | 0.71 | 0.74 | 0.39 | 0.00 | 0.38 | 1.07 | 0.00 | 0.98 | 0.57 | 0.56 | 0.20 | 0.78 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.83 | 1.33 | 1.82 | 0.00 |
| PKM | ENSG00000067225 | 0.00 | 0.25 | 0.21 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.71 | 0.74 | 0.00 | 0.00 | 1.13 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CBLN1 | ENSG00000102924 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LPO | ENSG00000167419 | 0.00 | 1.53 | 0.72 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.59 | 1.11 | 0.94 | 1.07 | 1.23 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 3.55 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| EBI3 | ENSG00000105246 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| CRLF1 | ENSG00000006016 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| CAPNS1 | ENSG00000126247 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IL1RN | ENSG00000136689 | 2.22 | 0.25 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 1.56 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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