Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CD99 | ENSG00000002586 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TM2D1 | ENSG00000162604 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.86 | 0.24 | 0.00 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| HSD11B1 | ENSG00000117594 | 1.11 | 0.00 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC22A24 | ENSG00000197658 | 1.11 | 0.25 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CHST11 | ENSG00000171310 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 0.19 | 0.64 | 1.23 | 0.00 | 1.15 | 0.00 | 0.61 | 1.56 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP8B3 | ENSG00000130270 | 1.11 | 1.53 | 0.83 | 1.09 | 0.00 | 1.29 | 0.00 | 1.66 | 1.55 | 0.60 | 0.00 | 1.36 | 1.07 | 0.74 | 0.59 | 0.83 | 1.69 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.81 | 0.00 | 0.20 | 0.83 | 1.11 | 3.64 | 0.00 |
| KCNK12 | ENSG00000184261 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RPN2 | ENSG00000118705 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| PKDREJ | ENSG00000130943 | 1.11 | 2.04 | 0.62 | 0.73 | 0.00 | 1.94 | 0.00 | 2.21 | 2.06 | 2.19 | 0.00 | 0.27 | 1.42 | 0.00 | 0.39 | 1.39 | 1.32 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 2.34 | 0.43 | 6.16 | 2.44 | 0.69 | 0.20 | 0.00 | 2.00 | 5.45 | 0.00 |
| SLC9A9 | ENSG00000181804 | 1.11 | 0.00 | 0.41 | 0.36 | 2.86 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 1.47 | 0.00 | 0.83 | 1.88 | 1.93 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| MFSD1 | ENSG00000118855 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CAMK2A | ENSG00000070808 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC35G5 | ENSG00000177710 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 1.50 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 1.42 | 0.54 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TRPM3 | ENSG00000083067 | 1.11 | 4.33 | 1.03 | 2.55 | 0.00 | 3.55 | 8.11 | 4.97 | 1.55 | 3.19 | 0.00 | 1.08 | 0.71 | 1.47 | 0.20 | 1.39 | 3.58 | 3.43 | 0.00 | 1.47 | 0.57 | 0.00 | 0.81 | 2.34 | 0.43 | 4.50 | 2.71 | 0.00 | 0.20 | 0.00 | 3.33 | 1.82 | 0.00 |
| WNT1 | ENSG00000125084 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 1.13 | 0.21 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PLA2G2F | ENSG00000158786 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PRKD1 | ENSG00000184304 | 1.11 | 2.80 | 0.62 | 1.09 | 0.00 | 3.23 | 2.70 | 2.21 | 0.52 | 2.99 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.56 | 4.14 | 3.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 1.56 | 0.86 | 1.18 | 2.44 | 0.00 | 0.61 | 0.00 | 2.44 | 0.00 | 1.25 |
| ALOX15B | ENSG00000179593 | 0.00 | 0.51 | 0.31 | 1.09 | 0.00 | 0.97 | 2.70 | 1.10 | 0.26 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.39 | 0.94 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 2.44 | 1.82 | 0.00 |
| PROC | ENSG00000115718 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MFNG | ENSG00000100060 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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