Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BTNL3 | ENSG00000168903 | 0.00 | 0.51 | 0.31 | 1.09 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.80 | 0.00 | 1.08 | 0.00 | 0.00 | 0.20 | 0.83 | 1.13 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.08 | 0.27 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 1.25 |
| BTNL9 | ENSG00000165810 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ENPP5 | ENSG00000112796 | 1.11 | 1.02 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 1.29 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| KCNQ5 | ENSG00000185760 | 0.00 | 2.80 | 0.72 | 1.09 | 0.00 | 2.26 | 0.00 | 1.66 | 1.03 | 0.80 | 1.54 | 0.54 | 0.36 | 0.00 | 0.00 | 1.11 | 1.88 | 2.79 | 0.00 | 1.47 | 0.57 | 0.00 | 0.41 | 4.69 | 1.29 | 9.48 | 2.71 | 0.00 | 0.20 | 0.83 | 2.44 | 0.00 | 0.00 |
| LRRN3 | ENSG00000173114 | 1.11 | 1.78 | 0.52 | 0.36 | 0.00 | 1.29 | 8.11 | 2.76 | 0.26 | 1.59 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.28 | 2.45 | 1.50 | 0.00 | 0.98 | 0.57 | 0.00 | 0.81 | 3.13 | 0.43 | 1.42 | 2.98 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TAS2R40 | ENSG00000221937 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 1.13 | 1.29 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ADAM7 | ENSG00000069206 | 0.00 | 1.02 | 0.21 | 1.46 | 0.00 | 2.26 | 0.00 | 2.21 | 1.29 | 1.39 | 0.00 | 0.00 | 1.07 | 0.00 | 0.78 | 1.11 | 1.88 | 2.36 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 12.32 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| KCNU1 | ENSG00000215262 | 0.00 | 2.29 | 0.83 | 1.09 | 0.00 | 2.26 | 2.70 | 2.21 | 1.29 | 1.20 | 0.00 | 0.27 | 0.71 | 0.74 | 0.78 | 1.39 | 6.59 | 3.43 | 1.23 | 1.23 | 0.00 | 0.00 | 0.41 | 2.34 | 0.43 | 3.79 | 3.25 | 0.00 | 0.41 | 0.00 | 2.22 | 0.00 | 1.25 |
| ADAM32 | ENSG00000197140 | 0.00 | 1.27 | 0.62 | 0.73 | 2.86 | 0.97 | 0.00 | 2.21 | 0.52 | 1.20 | 0.00 | 0.27 | 1.07 | 0.00 | 0.39 | 0.83 | 0.38 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.98 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ADAM18 | ENSG00000168619 | 0.00 | 1.02 | 0.31 | 1.09 | 0.00 | 1.61 | 0.00 | 3.31 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 1.47 | 0.00 | 2.50 | 1.69 | 4.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 13.03 | 1.08 | 0.00 | 0.20 | 0.83 | 1.11 | 0.00 | 0.00 |
| KCNQ3 | ENSG00000184156 | 1.11 | 2.29 | 1.14 | 1.09 | 2.86 | 3.23 | 2.70 | 4.97 | 0.52 | 2.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.39 | 1.32 | 4.51 | 1.23 | 0.98 | 1.72 | 0.00 | 0.20 | 3.13 | 0.00 | 8.53 | 1.63 | 0.00 | 0.00 | 0.00 | 3.55 | 1.82 | 0.00 |
| LY6D | ENSG00000167656 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PCSK5 | ENSG00000099139 | 0.00 | 2.54 | 1.14 | 1.09 | 0.00 | 1.61 | 8.11 | 1.66 | 0.52 | 1.79 | 1.54 | 0.27 | 1.07 | 0.00 | 0.39 | 0.83 | 3.95 | 2.79 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 1.29 | 12.09 | 1.08 | 0.69 | 0.00 | 0.83 | 2.88 | 0.00 | 0.00 |
| IL1RAPL2 | ENSG00000189108 | 1.11 | 1.02 | 0.31 | 0.73 | 0.00 | 2.58 | 0.00 | 1.10 | 0.77 | 1.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.98 | 1.67 | 3.58 | 2.36 | 1.23 | 1.23 | 0.00 | 0.00 | 0.61 | 2.34 | 0.00 | 3.32 | 1.90 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| SLC6A17 | ENSG00000197106 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 1.61 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.54 | 1.07 | 0.00 | 0.20 | 0.83 | 1.51 | 2.15 | 1.23 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CACNA1E | ENSG00000198216 | 1.11 | 4.07 | 2.69 | 4.38 | 2.86 | 9.03 | 5.41 | 3.31 | 1.80 | 3.59 | 0.00 | 0.81 | 1.07 | 0.00 | 1.18 | 6.94 | 12.05 | 10.09 | 0.00 | 0.98 | 0.57 | 0.00 | 2.85 | 7.03 | 1.29 | 16.82 | 4.88 | 0.69 | 0.61 | 0.00 | 7.76 | 3.64 | 0.00 |
| COL13A1 | ENSG00000197467 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 1.51 | 2.79 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CHST3 | ENSG00000122863 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.39 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.13 | 0.00 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| SLC17A6 | ENSG00000091664 | 0.00 | 1.53 | 0.62 | 0.73 | 2.86 | 0.97 | 0.00 | 3.31 | 1.03 | 1.20 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.83 | 4.71 | 5.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 1.29 | 5.45 | 2.98 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| KCNH3 | ENSG00000135519 | 0.00 | 2.29 | 0.52 | 1.09 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 1.20 | 0.00 | 0.27 | 1.42 | 0.74 | 0.20 | 0.28 | 1.69 | 1.72 | 1.23 | 0.49 | 1.15 | 0.56 | 0.20 | 0.78 | 0.86 | 2.13 | 1.08 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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