Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SIGLEC8 | ENSG00000105366 | 0.00 | 1.02 | 0.62 | 0.73 | 0.00 | 3.23 | 0.00 | 0.00 | 1.29 | 0.60 | 0.00 | 1.08 | 0.00 | 0.00 | 0.20 | 1.11 | 2.26 | 2.15 | 0.00 | 1.23 | 0.57 | 0.00 | 0.20 | 1.56 | 0.43 | 4.03 | 0.54 | 0.00 | 0.20 | 1.65 | 1.11 | 0.00 | 0.00 |
| SLC9A2 | ENSG00000115616 | 0.00 | 1.02 | 0.93 | 1.82 | 0.00 | 0.32 | 2.70 | 0.55 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 2.64 | 4.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 5.92 | 1.36 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CNTNAP5 | ENSG00000155052 | 6.67 | 3.05 | 1.24 | 1.46 | 2.86 | 1.94 | 8.11 | 8.84 | 1.55 | 4.58 | 0.00 | 0.27 | 2.49 | 1.47 | 0.00 | 1.94 | 10.55 | 15.24 | 0.00 | 3.19 | 0.57 | 0.56 | 2.04 | 3.91 | 2.16 | 10.66 | 8.40 | 0.00 | 0.20 | 0.00 | 5.76 | 0.00 | 1.25 |
| SLC38A11 | ENSG00000169507 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 0.54 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SCN1A | ENSG00000144285 | 1.11 | 6.11 | 1.45 | 1.09 | 0.00 | 6.45 | 5.41 | 4.42 | 1.80 | 5.58 | 1.54 | 1.08 | 1.07 | 1.47 | 0.59 | 1.94 | 3.95 | 11.80 | 1.23 | 2.70 | 1.72 | 0.00 | 1.02 | 0.78 | 2.16 | 13.98 | 3.25 | 0.00 | 0.41 | 1.65 | 4.43 | 0.00 | 0.00 |
| TMEFF2 | ENSG00000144339 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.86 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC24A3 | ENSG00000185052 | 1.11 | 1.53 | 0.31 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.78 | 0.83 | 0.94 | 2.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 4.27 | 0.00 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| SLC32A1 | ENSG00000101438 | 1.11 | 2.29 | 0.00 | 0.73 | 2.86 | 3.55 | 2.70 | 0.00 | 0.26 | 0.80 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 3.01 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.18 | 2.44 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC2A10 | ENSG00000197496 | 0.00 | 1.27 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 2.45 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 2.61 | 0.54 | 0.69 | 0.00 | 0.83 | 0.22 | 0.00 | 1.25 |
| KCNB1 | ENSG00000158445 | 1.11 | 1.78 | 0.41 | 1.09 | 0.00 | 1.61 | 2.70 | 0.55 | 1.29 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 3.95 | 1.93 | 0.00 | 0.25 | 0.00 | 0.56 | 0.61 | 0.00 | 0.00 | 8.29 | 1.90 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| KCNQ2 | ENSG00000075043 | 0.00 | 1.02 | 0.83 | 0.36 | 0.00 | 3.23 | 0.00 | 1.66 | 0.52 | 0.60 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 1.11 | 3.20 | 2.79 | 2.47 | 0.49 | 1.15 | 0.00 | 0.41 | 1.56 | 1.29 | 3.32 | 2.71 | 0.00 | 0.00 | 0.00 | 3.99 | 0.00 | 0.00 |
| TMPRSS15 | ENSG00000154646 | 0.00 | 2.80 | 1.03 | 0.73 | 0.00 | 2.58 | 0.00 | 0.55 | 1.80 | 1.00 | 1.54 | 1.08 | 0.36 | 0.00 | 1.18 | 1.39 | 6.97 | 6.65 | 0.00 | 1.96 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 4.74 | 3.52 | 0.69 | 0.61 | 0.00 | 1.77 | 5.45 | 0.00 |
| EPHA6 | ENSG00000080224 | 1.11 | 2.29 | 0.52 | 1.46 | 0.00 | 1.61 | 5.41 | 2.21 | 1.29 | 2.59 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 1.39 | 8.47 | 7.30 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 2.34 | 1.29 | 11.61 | 4.61 | 0.69 | 0.41 | 0.00 | 1.55 | 0.00 | 0.00 |
| IMPG2 | ENSG00000081148 | 0.00 | 4.07 | 0.62 | 1.46 | 2.86 | 0.65 | 0.00 | 3.31 | 0.52 | 2.79 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.56 | 2.82 | 4.51 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 2.61 | 2.44 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| RPN1 | ENSG00000163902 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IL20RB | ENSG00000174564 | 2.22 | 0.51 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OTOP1 | ENSG00000163982 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 0.77 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.78 | 0.56 | 1.51 | 1.72 | 2.47 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.83 | 0.89 | 1.82 | 0.00 |
| ATP8A1 | ENSG00000124406 | 1.11 | 2.54 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 3.87 | 0.52 | 2.79 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 2.22 | 0.75 | 3.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 1.29 | 4.98 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ATP10D | ENSG00000145246 | 0.00 | 2.04 | 0.93 | 1.09 | 0.00 | 1.29 | 2.70 | 4.42 | 1.29 | 1.59 | 0.00 | 1.08 | 0.71 | 0.00 | 0.78 | 1.67 | 3.39 | 5.15 | 0.00 | 0.49 | 0.57 | 0.56 | 0.41 | 1.56 | 0.43 | 7.58 | 2.71 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 1.25 |
| UGT8 | ENSG00000174607 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.13 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
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