Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLAMF8 | ENSG00000158714 | 0.00 | 0.51 | 0.10 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.13 | 0.54 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| NRXN2 | ENSG00000110076 | 1.11 | 1.78 | 0.83 | 1.09 | 0.00 | 3.23 | 0.00 | 2.21 | 0.52 | 1.20 | 0.00 | 1.08 | 0.71 | 1.47 | 0.00 | 0.28 | 3.77 | 2.79 | 0.00 | 0.98 | 1.72 | 0.00 | 0.00 | 2.34 | 0.86 | 2.84 | 1.36 | 0.00 | 0.20 | 0.00 | 3.10 | 1.82 | 0.00 |
| NAALAD2 | ENSG00000077616 | 1.11 | 0.76 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 1.29 | 1.39 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.83 | 3.20 | 4.08 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 2.34 | 0.86 | 4.98 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| HEPHL1 | ENSG00000181333 | 1.11 | 2.80 | 0.72 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 1.03 | 0.80 | 0.00 | 0.54 | 1.07 | 2.21 | 0.39 | 0.56 | 3.01 | 3.86 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 0.78 | 1.29 | 8.53 | 1.36 | 0.69 | 0.00 | 0.00 | 3.33 | 3.64 | 0.00 |
| ABCG4 | ENSG00000172350 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 1.39 | 0.00 | 0.54 | 1.07 | 0.74 | 0.59 | 0.83 | 2.45 | 2.36 | 0.00 | 1.23 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC37A2 | ENSG00000134955 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TAS2R50 | ENSG00000212126 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 1.54 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR8S1 | ENSG00000197376 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| AMHR2 | ENSG00000135409 | 1.11 | 0.25 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.56 | 1.13 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.84 | 0.00 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ATP2A2 | ENSG00000174437 | 2.22 | 1.53 | 0.10 | 1.46 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 1.39 | 1.88 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 2.84 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| TNFRSF19 | ENSG00000127863 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 1.13 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| TRPC4 | ENSG00000133107 | 0.00 | 3.05 | 0.52 | 0.73 | 2.86 | 4.19 | 0.00 | 3.31 | 0.26 | 2.19 | 0.00 | 0.54 | 0.36 | 0.74 | 0.59 | 0.56 | 5.65 | 3.43 | 1.23 | 1.72 | 0.57 | 0.00 | 0.41 | 3.91 | 0.00 | 7.35 | 3.25 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| ADAM21 | ENSG00000139985 | 0.00 | 1.78 | 0.41 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 3.22 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 5.69 | 1.36 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ADAM20 | ENSG00000134007 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 1.39 | 0.00 | 0.27 | 1.07 | 2.94 | 0.39 | 0.56 | 1.32 | 1.29 | 0.00 | 0.25 | 0.00 | 1.12 | 0.20 | 1.56 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC5A11 | ENSG00000158865 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 1.36 | 0.00 | 0.00 | 0.39 | 0.83 | 2.45 | 2.58 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 1.29 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SPNS3 | ENSG00000182557 | 1.11 | 0.51 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 1.32 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| KCNJ16 | ENSG00000153822 | 0.00 | 1.78 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 1.29 | 0.00 | 0.00 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.95 | 1.36 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 1.25 |
| CD209 | ENSG00000090659 | 1.11 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 1.80 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.78 | 0.28 | 0.75 | 2.15 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 2.84 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| CEACAM3 | ENSG00000170956 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 1.39 | 0.19 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SIGLEC11 | ENSG00000161640 | 0.00 | 1.02 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 1.03 | 0.40 | 0.00 | 0.54 | 0.36 | 1.47 | 0.20 | 0.83 | 1.13 | 1.07 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 0.00 | 0.43 | 4.74 | 0.81 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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