Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TAS2R39 | ENSG00000236398 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LRRC55 | ENSG00000183908 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 2.06 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 0.75 | 1.93 | 1.23 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| TAPBPL | ENSG00000139192 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TAS2R7 | ENSG00000121377 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.81 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| TAS2R8 | ENSG00000121314 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.98 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TAS2R9 | ENSG00000121381 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TAS2R30 | ENSG00000256188 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 2.70 | 1.66 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| HCN4 | ENSG00000138622 | 0.00 | 1.02 | 0.52 | 0.73 | 0.00 | 0.97 | 2.70 | 1.10 | 0.00 | 1.99 | 1.54 | 0.54 | 0.00 | 0.74 | 0.59 | 1.67 | 1.88 | 1.72 | 0.00 | 0.98 | 1.72 | 0.00 | 0.61 | 2.34 | 0.43 | 4.03 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| NETO2 | ENSG00000171208 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.28 | 1.13 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CACNA1G | ENSG00000006283 | 1.11 | 3.31 | 0.83 | 1.82 | 2.86 | 2.58 | 5.41 | 2.21 | 0.52 | 2.99 | 1.54 | 1.08 | 1.07 | 0.00 | 0.59 | 1.67 | 3.58 | 3.22 | 0.00 | 0.98 | 1.72 | 0.00 | 0.20 | 0.78 | 0.86 | 6.64 | 2.98 | 0.00 | 0.41 | 0.00 | 4.66 | 0.00 | 0.00 |
| PSENEN | ENSG00000205155 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| VAMP8 | ENSG00000118640 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TAS2R1 | ENSG00000169777 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 2.70 | 0.00 | 0.77 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 3.20 | 1.72 | 0.00 | 1.96 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 1.08 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| SLC17A3 | ENSG00000124564 | 0.00 | 1.27 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.83 | 2.64 | 2.79 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OPN5 | ENSG00000124818 | 1.11 | 0.76 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 2.26 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TAS2R3 | ENSG00000127362 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 2.21 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TAS2R38 | ENSG00000257138 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2A42 | ENSG00000212807 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADAM30 | ENSG00000134249 | 1.11 | 2.29 | 0.52 | 1.09 | 5.71 | 0.65 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.83 | 1.51 | 1.07 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.84 | 1.08 | 0.00 | 0.00 | 0.83 | 1.77 | 1.82 | 0.00 |
| RHBG | ENSG00000132677 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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