Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| IFNL1 | ENSG00000182393 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CPO | ENSG00000144410 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SRC | ENSG00000197122 | 0.00 | 1.53 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.19 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| LIPH | ENSG00000163898 | 0.00 | 1.53 | 0.31 | 1.46 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| GZMA | ENSG00000145649 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 1.29 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PLG | ENSG00000122194 | 1.11 | 1.02 | 0.93 | 1.46 | 0.00 | 1.29 | 2.70 | 1.66 | 1.03 | 2.19 | 0.00 | 1.63 | 0.00 | 0.74 | 0.39 | 0.83 | 4.52 | 2.79 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 2.34 | 0.43 | 9.24 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| IL6 | ENSG00000136244 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR2F1 | ENSG00000213215 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PGLYRP4 | ENSG00000163218 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 1.67 | 0.75 | 0.21 | 0.00 | 0.98 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 3.55 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| S100A9 | ENSG00000163220 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLIT1 | ENSG00000187122 | 1.11 | 2.54 | 0.31 | 1.46 | 0.00 | 2.90 | 0.00 | 1.10 | 0.26 | 1.20 | 1.54 | 1.08 | 0.00 | 0.00 | 0.98 | 1.39 | 2.82 | 1.93 | 2.47 | 1.23 | 1.72 | 0.56 | 0.41 | 1.56 | 0.43 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| GIF | ENSG00000134812 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.94 | 1.72 | 0.00 | 0.25 | 1.15 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CST6 | ENSG00000175315 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.83 | 0.00 | 0.00 | 0.00 |
| MAPT | ENSG00000186868 | 0.00 | 1.53 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 1.20 | 1.54 | 0.54 | 0.36 | 0.00 | 0.00 | 0.83 | 2.26 | 1.50 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 1.56 | 0.43 | 2.13 | 0.27 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| TEC | ENSG00000135605 | 1.11 | 2.04 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.59 | 0.00 | 1.69 | 1.93 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IL15 | ENSG00000164136 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADAMTS2 | ENSG00000087116 | 2.22 | 2.29 | 1.14 | 1.46 | 0.00 | 3.87 | 0.00 | 4.42 | 1.29 | 0.80 | 1.54 | 1.08 | 0.36 | 0.00 | 0.78 | 1.67 | 6.03 | 2.58 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 0.78 | 0.43 | 6.16 | 1.63 | 0.00 | 0.20 | 0.00 | 2.88 | 1.82 | 0.00 |
| PON3 | ENSG00000105852 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.00 | 1.20 | 1.54 | 0.81 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RELN | ENSG00000189056 | 4.44 | 6.62 | 2.48 | 3.28 | 0.00 | 5.81 | 0.00 | 4.97 | 4.12 | 8.17 | 0.00 | 1.90 | 1.07 | 0.74 | 0.98 | 3.06 | 11.49 | 15.45 | 2.47 | 3.92 | 2.87 | 0.00 | 1.02 | 5.47 | 1.72 | 14.69 | 5.42 | 0.00 | 0.41 | 0.00 | 5.54 | 1.82 | 1.25 |
| AOC1 | ENSG00000002726 | 0.00 | 1.78 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 1.80 | 1.20 | 0.00 | 1.08 | 0.36 | 0.00 | 0.59 | 0.56 | 2.45 | 2.58 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 5.21 | 0.81 | 0.00 | 0.61 | 0.00 | 2.66 | 1.82 | 0.00 |
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