Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ASIC4 | ENSG00000072182 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.83 | 2.07 | 1.93 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 1.56 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| KCNJ6 | ENSG00000157542 | 1.11 | 1.53 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.83 | 1.13 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 2.34 | 0.86 | 4.74 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ABCG1 | ENSG00000160179 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 0.56 | 1.13 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| LTB | ENSG00000227507 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 8.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KCNK17 | ENSG00000124780 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ENPP7 | ENSG00000182156 | 0.00 | 1.27 | 0.62 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 1.29 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 1.82 | 0.00 |
| CPAMD8 | ENSG00000160111 | 0.00 | 1.78 | 1.03 | 1.82 | 0.00 | 2.26 | 5.41 | 2.21 | 1.03 | 3.19 | 0.00 | 1.36 | 0.00 | 0.74 | 1.18 | 2.22 | 3.20 | 4.29 | 0.00 | 2.21 | 0.57 | 0.00 | 0.41 | 1.56 | 1.29 | 12.80 | 3.52 | 0.00 | 0.00 | 0.00 | 5.32 | 0.00 | 1.25 |
| SEMA3D | ENSG00000153993 | 1.11 | 4.07 | 1.55 | 0.00 | 0.00 | 1.94 | 2.70 | 2.76 | 0.00 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 1.94 | 3.77 | 2.79 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 3.55 | 2.44 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| XPNPEP2 | ENSG00000122121 | 0.00 | 0.51 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 1.08 | 0.36 | 0.00 | 0.00 | 0.28 | 1.88 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.18 | 1.08 | 0.69 | 0.00 | 0.83 | 2.44 | 0.00 | 0.00 |
| SSH1 | ENSG00000084112 | 1.11 | 1.02 | 0.31 | 1.46 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 0.94 | 1.29 | 0.00 | 1.47 | 0.00 | 0.56 | 0.41 | 0.00 | 0.43 | 3.08 | 0.81 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 1.25 |
| PDE4A | ENSG00000065989 | 0.00 | 2.29 | 0.21 | 0.73 | 2.86 | 1.29 | 2.70 | 1.10 | 0.26 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 0.64 | 1.23 | 1.72 | 0.00 | 0.56 | 0.41 | 0.00 | 0.43 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD160 | ENSG00000117281 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 1.25 |
| PRSS21 | ENSG00000007038 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CFC1 | ENSG00000136698 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.88 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HCK | ENSG00000101336 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.77 | 0.00 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.00 | 2.07 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 0.86 | 3.32 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CNTN4 | ENSG00000144619 | 1.11 | 2.04 | 0.62 | 1.09 | 0.00 | 1.94 | 0.00 | 2.76 | 1.80 | 2.19 | 0.00 | 0.00 | 0.71 | 0.00 | 0.98 | 0.56 | 3.20 | 3.65 | 0.00 | 0.98 | 1.15 | 0.00 | 0.20 | 3.91 | 0.00 | 11.37 | 4.07 | 0.00 | 0.00 | 0.00 | 2.66 | 1.82 | 0.00 |
| WNT8A | ENSG00000061492 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LPL | ENSG00000175445 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 1.42 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.86 | 0.95 | 1.08 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR4X2 | ENSG00000172208 | 0.00 | 1.53 | 0.62 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 1.13 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SPHK1 | ENSG00000176170 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 1.11 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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