Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC35G2 | ENSG00000168917 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC2A2 | ENSG00000163581 | 0.00 | 1.78 | 0.10 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.99 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 1.39 | 0.38 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC10A4 | ENSG00000145248 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC6A18 | ENSG00000164363 | 0.00 | 0.51 | 0.31 | 0.36 | 2.86 | 0.00 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.00 | 2.45 | 1.72 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 1.08 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC6A7 | ENSG00000011083 | 1.11 | 1.53 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.94 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TNF | ENSG00000232810 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.19 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNK5 | ENSG00000164626 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.39 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| SLC22A2 | ENSG00000112499 | 1.11 | 1.27 | 0.52 | 1.46 | 0.00 | 0.32 | 2.70 | 1.66 | 0.77 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.28 | 1.13 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 4.74 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC13A4 | ENSG00000164707 | 0.00 | 1.27 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 2.21 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 0.83 | 0.56 | 0.86 | 2.47 | 0.49 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC34A3 | ENSG00000198569 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CACNA1B | ENSG00000148408 | 0.00 | 3.31 | 1.86 | 2.19 | 0.00 | 3.87 | 0.00 | 1.66 | 1.80 | 1.39 | 0.00 | 0.54 | 1.07 | 2.21 | 0.59 | 3.33 | 5.46 | 5.15 | 1.23 | 0.98 | 4.02 | 0.00 | 0.41 | 2.34 | 1.29 | 6.40 | 2.71 | 0.00 | 0.61 | 0.00 | 3.77 | 3.64 | 1.25 |
| TSPAN7 | ENSG00000156298 | 1.11 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| EBP | ENSG00000147155 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KCNA10 | ENSG00000143105 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.11 | 0.94 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TECTB | ENSG00000119913 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 1.29 | 2.47 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ART1 | ENSG00000129744 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| KCNG2 | ENSG00000178342 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC27A1 | ENSG00000130304 | 1.11 | 1.27 | 0.21 | 1.09 | 0.00 | 0.65 | 2.70 | 0.00 | 0.77 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| KCNA7 | ENSG00000104848 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC20A1 | ENSG00000144136 | 0.00 | 1.78 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 0.83 | 0.38 | 1.29 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
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