Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ATP8A2 | ENSG00000132932 | 1.11 | 2.29 | 0.41 | 1.09 | 0.00 | 1.94 | 2.70 | 0.55 | 1.80 | 2.59 | 0.00 | 1.36 | 0.36 | 0.00 | 0.20 | 2.22 | 4.52 | 3.65 | 0.00 | 1.23 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 2.61 | 1.90 | 1.39 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ADCY4 | ENSG00000129467 | 1.11 | 1.27 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.59 | 1.54 | 0.27 | 0.36 | 0.74 | 0.59 | 0.56 | 1.32 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC10A1 | ENSG00000100652 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.38 | 0.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC28A2 | ENSG00000137860 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 1.32 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 1.90 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC24A5 | ENSG00000188467 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 1.51 | 2.58 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC12A1 | ENSG00000074803 | 0.00 | 1.53 | 0.21 | 1.46 | 0.00 | 1.94 | 2.70 | 2.76 | 0.26 | 1.59 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 1.11 | 4.33 | 4.08 | 1.23 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 2.84 | 2.44 | 0.00 | 0.00 | 0.83 | 3.10 | 0.00 | 0.00 |
| AQP9 | ENSG00000103569 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 2.13 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| AQP8 | ENSG00000103375 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC5A2 | ENSG00000140675 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.39 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.86 | 0.47 | 0.00 | 0.00 | 0.41 | 0.00 | 2.22 | 0.00 | 0.00 |
| SLC5A10 | ENSG00000154025 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 2.70 | 1.10 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CACNG5 | ENSG00000075429 | 0.00 | 1.02 | 0.21 | 0.00 | 2.86 | 0.97 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC5A5 | ENSG00000105641 | 3.33 | 1.53 | 0.31 | 0.00 | 0.00 | 1.29 | 2.70 | 0.00 | 0.00 | 1.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.56 | 0.56 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.90 | 1.08 | 0.69 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC7A10 | ENSG00000130876 | 1.11 | 1.27 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TEX101 | ENSG00000131126 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| LYPD5 | ENSG00000159871 | 1.11 | 0.25 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC17A7 | ENSG00000104888 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| P2RX6 | ENSG00000099957 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SLC5A4 | ENSG00000100191 | 0.00 | 1.27 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 1.03 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 1.88 | 2.58 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.81 | 0.69 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CACNA1I | ENSG00000100346 | 2.22 | 1.53 | 0.52 | 1.46 | 0.00 | 2.26 | 0.00 | 1.66 | 1.29 | 1.20 | 0.00 | 0.81 | 0.71 | 0.74 | 0.78 | 1.67 | 3.01 | 4.29 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 1.56 | 0.86 | 5.92 | 2.44 | 0.69 | 0.00 | 0.83 | 3.10 | 0.00 | 0.00 |
| TNFRSF13C | ENSG00000159958 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 5.41 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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