Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADAM29 | ENSG00000168594 | 0.00 | 3.31 | 1.14 | 0.73 | 0.00 | 2.26 | 0.00 | 2.21 | 3.35 | 2.39 | 0.00 | 1.08 | 0.36 | 0.00 | 0.00 | 1.11 | 3.20 | 3.43 | 0.00 | 0.98 | 0.57 | 0.00 | 1.43 | 2.34 | 0.00 | 10.43 | 1.08 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| MEP1A | ENSG00000112818 | 0.00 | 1.53 | 0.62 | 1.82 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.59 | 1.11 | 0.94 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 5.21 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ULBP1 | ENSG00000111981 | 0.00 | 0.51 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| LRRC4 | ENSG00000128594 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| EPHB6 | ENSG00000106123 | 0.00 | 1.78 | 0.41 | 1.46 | 0.00 | 0.97 | 0.00 | 1.66 | 0.77 | 1.39 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 0.56 | 5.65 | 3.22 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 5.69 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ADAM2 | ENSG00000104755 | 1.11 | 2.04 | 0.41 | 0.00 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 2.19 | 0.00 | 0.54 | 0.71 | 0.74 | 0.78 | 1.11 | 4.14 | 4.94 | 0.00 | 0.98 | 1.72 | 0.56 | 0.20 | 0.00 | 0.43 | 7.35 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| LINGO2 | ENSG00000174482 | 0.00 | 0.51 | 0.83 | 1.46 | 0.00 | 2.58 | 0.00 | 0.55 | 1.55 | 2.19 | 0.00 | 0.27 | 0.00 | 0.74 | 0.59 | 1.11 | 2.26 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 1.22 | 2.34 | 0.86 | 3.79 | 2.98 | 0.00 | 0.20 | 0.00 | 2.00 | 1.82 | 0.00 |
| SLC46A2 | ENSG00000119457 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TNFSF15 | ENSG00000181634 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| TNFSF8 | ENSG00000106952 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TLR7 | ENSG00000196664 | 0.00 | 1.53 | 1.24 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 1.55 | 1.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.98 | 0.56 | 3.01 | 2.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.55 | 0.54 | 1.39 | 0.20 | 0.00 | 2.66 | 1.82 | 0.00 |
| ADGRG4 | ENSG00000156920 | 2.22 | 4.07 | 1.76 | 3.65 | 0.00 | 2.26 | 0.00 | 2.21 | 1.55 | 4.98 | 0.00 | 2.98 | 0.36 | 2.94 | 1.76 | 3.06 | 14.88 | 10.73 | 0.00 | 2.70 | 2.30 | 0.00 | 1.22 | 7.03 | 0.86 | 16.82 | 3.79 | 0.00 | 0.00 | 0.83 | 7.54 | 1.82 | 1.25 |
| SLC5A9 | ENSG00000117834 | 1.11 | 1.78 | 0.21 | 0.73 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 1.32 | 1.72 | 1.23 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC1A7 | ENSG00000162383 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.81 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC16A9 | ENSG00000165449 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.83 | 0.75 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 4.27 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC18A2 | ENSG00000165646 | 0.00 | 0.51 | 0.21 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.56 | 1.88 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC43A3 | ENSG00000134802 | 1.11 | 0.00 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.38 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TECTA | ENSG00000109927 | 1.11 | 3.82 | 0.83 | 0.36 | 0.00 | 5.81 | 2.70 | 2.76 | 1.55 | 1.59 | 0.00 | 0.54 | 1.42 | 0.74 | 0.20 | 1.67 | 4.52 | 6.22 | 1.23 | 2.94 | 0.57 | 0.00 | 0.41 | 4.69 | 2.16 | 8.06 | 6.23 | 0.69 | 0.20 | 0.83 | 4.21 | 0.00 | 1.25 |
| KCNJ1 | ENSG00000151704 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 1.32 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 3.13 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LRIG3 | ENSG00000139263 | 1.11 | 2.29 | 0.62 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.54 | 2.14 | 0.00 | 0.00 | 1.11 | 1.51 | 1.93 | 0.00 | 0.25 | 0.57 | 0.00 | 0.61 | 1.56 | 0.43 | 2.61 | 1.08 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
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