Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CHRNA10 | ENSG00000129749 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| LRRC4C | ENSG00000148948 | 2.22 | 1.78 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 3.87 | 1.29 | 5.18 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 1.67 | 5.65 | 6.65 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 3.13 | 0.00 | 9.48 | 0.54 | 0.00 | 0.41 | 0.00 | 1.11 | 1.82 | 0.00 |
| SLC22A9 | ENSG00000149742 | 0.00 | 0.76 | 0.41 | 1.09 | 0.00 | 0.00 | 2.70 | 0.55 | 1.55 | 0.40 | 0.00 | 1.36 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 2.58 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 6.64 | 0.54 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| CRTAM | ENSG00000109943 | 0.00 | 1.27 | 0.31 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 1.50 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SCN3B | ENSG00000166257 | 0.00 | 0.51 | 0.21 | 0.00 | 2.86 | 0.97 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.75 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| VSIG2 | ENSG00000019102 | 1.11 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.81 | 0.69 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| ABCC9 | ENSG00000069431 | 1.11 | 3.31 | 1.45 | 1.82 | 0.00 | 1.94 | 0.00 | 4.97 | 3.09 | 3.39 | 0.00 | 1.08 | 0.71 | 0.00 | 0.59 | 0.83 | 3.39 | 5.79 | 1.23 | 1.72 | 1.72 | 0.56 | 0.41 | 1.56 | 0.43 | 9.95 | 6.23 | 0.69 | 0.20 | 0.00 | 3.10 | 0.00 | 0.00 |
| TPSG1 | ENSG00000116176 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| CNTNAP4 | ENSG00000152910 | 1.11 | 4.33 | 0.62 | 2.55 | 0.00 | 3.23 | 5.41 | 2.21 | 0.77 | 2.59 | 0.00 | 1.36 | 0.71 | 0.74 | 0.20 | 0.83 | 7.16 | 9.23 | 1.23 | 1.23 | 1.15 | 0.00 | 0.41 | 2.34 | 1.29 | 9.72 | 2.71 | 0.69 | 0.20 | 0.83 | 2.66 | 0.00 | 0.00 |
| SLC13A2 | ENSG00000007216 | 1.11 | 0.51 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.56 | 1.13 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 2.17 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADAM11 | ENSG00000073670 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.54 | 1.07 | 0.74 | 0.00 | 0.56 | 1.51 | 1.07 | 0.00 | 0.49 | 1.15 | 0.00 | 0.41 | 0.78 | 0.86 | 3.79 | 0.27 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC1A6 | ENSG00000105143 | 0.00 | 0.76 | 0.83 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 2.32 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.78 | 1.11 | 2.45 | 1.72 | 1.23 | 0.74 | 0.00 | 0.00 | 0.41 | 3.13 | 0.43 | 3.55 | 1.63 | 0.00 | 0.41 | 0.00 | 1.55 | 1.82 | 0.00 |
| EDAR | ENSG00000135960 | 0.00 | 0.76 | 0.62 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.98 | 0.28 | 1.13 | 1.07 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 1.56 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| MMP24 | ENSG00000125966 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 1.07 | 0.74 | 0.00 | 0.00 | 0.56 | 0.00 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.90 | 0.00 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| CACNG2 | ENSG00000166862 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 0.56 | 0.86 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| UPK3A | ENSG00000100373 | 1.11 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IL17RE | ENSG00000163701 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC22A14 | ENSG00000144671 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 3.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| TLR10 | ENSG00000174123 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 1.66 | 0.77 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.00 | 1.88 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| EPGN | ENSG00000182585 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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