Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GPR31 | ENSG00000120436 | 0.00 | 1.27 | 0.21 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GPR22 | ENSG00000172209 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GPR34 | ENSG00000171659 | 1.11 | 0.00 | 0.21 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| AVPR2 | ENSG00000126895 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 1.50 | 2.47 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AQP10 | ENSG00000143595 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 1.69 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ISLR2 | ENSG00000167178 | 0.00 | 0.76 | 0.41 | 1.46 | 0.00 | 0.97 | 2.70 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 1.32 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| GP2 | ENSG00000169347 | 0.00 | 2.04 | 0.10 | 0.00 | 0.00 | 0.65 | 8.11 | 1.10 | 0.00 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 2.45 | 3.22 | 0.00 | 1.23 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 2.37 | 1.08 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| TPO | ENSG00000115705 | 1.11 | 3.31 | 0.83 | 1.09 | 0.00 | 2.58 | 8.11 | 2.21 | 2.32 | 1.79 | 0.00 | 0.54 | 0.36 | 0.74 | 0.39 | 4.17 | 4.52 | 4.08 | 0.00 | 0.74 | 2.87 | 0.56 | 0.61 | 3.13 | 0.00 | 8.53 | 4.61 | 0.00 | 0.20 | 0.00 | 2.88 | 1.82 | 0.00 |
| ACVR1C | ENSG00000123612 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.39 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 3.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADGRG7 | ENSG00000144820 | 0.00 | 0.76 | 0.31 | 1.46 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.59 | 0.28 | 2.64 | 2.58 | 0.00 | 2.21 | 1.15 | 1.12 | 0.20 | 0.78 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| RRH | ENSG00000180245 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PCDHA2 | ENSG00000204969 | 2.22 | 3.56 | 0.72 | 3.28 | 0.00 | 5.16 | 2.70 | 1.10 | 2.06 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.98 | 1.39 | 5.84 | 3.43 | 1.23 | 1.96 | 1.72 | 0.00 | 0.61 | 0.78 | 0.86 | 4.98 | 1.36 | 0.00 | 0.00 | 0.00 | 4.21 | 3.64 | 0.00 |
| GABRG2 | ENSG00000113327 | 0.00 | 1.27 | 0.52 | 1.09 | 0.00 | 0.32 | 0.00 | 1.10 | 1.55 | 1.39 | 0.00 | 1.08 | 1.07 | 0.00 | 0.20 | 1.39 | 4.14 | 3.65 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 3.13 | 0.00 | 5.21 | 2.44 | 0.69 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ADGRF4 | ENSG00000153294 | 0.00 | 1.02 | 0.10 | 1.46 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.74 | 0.78 | 0.28 | 2.26 | 2.58 | 0.00 | 0.98 | 0.57 | 0.00 | 0.61 | 0.00 | 0.86 | 3.79 | 1.08 | 0.69 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADGRD2 | ENSG00000180264 | 1.11 | 0.00 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| EDA | ENSG00000158813 | 0.00 | 1.27 | 0.21 | 1.09 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| OPN1LW | ENSG00000102076 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC2A7 | ENSG00000197241 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| EPHA8 | ENSG00000070886 | 1.11 | 2.29 | 0.00 | 2.19 | 2.86 | 0.97 | 0.00 | 0.55 | 1.55 | 1.00 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 1.11 | 2.45 | 3.00 | 0.00 | 0.74 | 1.15 | 0.00 | 0.20 | 0.78 | 0.86 | 3.79 | 2.17 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| INSRR | ENSG00000027644 | 1.11 | 2.54 | 0.83 | 1.46 | 0.00 | 1.61 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.81 | 1.78 | 0.00 | 0.20 | 1.67 | 4.90 | 4.51 | 0.00 | 1.72 | 0.57 | 0.00 | 0.81 | 1.56 | 0.00 | 6.64 | 2.17 | 0.00 | 0.00 | 0.00 | 3.33 | 3.64 | 0.00 |
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