Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| IL13 | ENSG00000169194 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| EPDR1 | ENSG00000086289 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.59 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| C8B | ENSG00000021852 | 1.11 | 0.76 | 0.10 | 0.36 | 0.00 | 1.94 | 0.00 | 1.10 | 1.03 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.83 | 3.01 | 2.15 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 9.48 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| OLFML2B | ENSG00000162745 | 1.11 | 0.76 | 0.62 | 1.09 | 0.00 | 0.97 | 0.00 | 2.76 | 0.52 | 1.39 | 0.00 | 0.27 | 1.07 | 0.00 | 0.39 | 1.11 | 2.82 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 3.08 | 2.98 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| OR52B4 | ENSG00000221996 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 3.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 4.50 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR5AR1 | ENSG00000172459 | 1.11 | 0.76 | 0.00 | 0.73 | 0.00 | 1.29 | 0.00 | 1.10 | 1.80 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 2.45 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.13 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| FBN2 | ENSG00000138829 | 4.44 | 7.12 | 1.03 | 3.28 | 5.71 | 3.55 | 2.70 | 4.97 | 3.35 | 3.98 | 0.00 | 4.07 | 1.07 | 0.00 | 1.37 | 5.56 | 12.62 | 7.94 | 1.23 | 1.72 | 2.30 | 0.00 | 0.61 | 2.34 | 1.72 | 8.29 | 4.07 | 0.00 | 0.20 | 0.00 | 5.10 | 1.82 | 0.00 |
| NELL1 | ENSG00000165973 | 2.22 | 1.78 | 0.62 | 1.09 | 2.86 | 1.29 | 2.70 | 3.87 | 1.03 | 2.59 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 0.83 | 8.29 | 5.79 | 0.00 | 0.98 | 0.57 | 0.00 | 0.61 | 1.56 | 0.43 | 5.21 | 3.25 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PRSS23 | ENSG00000150687 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL17D | ENSG00000172458 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CTSG | ENSG00000100448 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 1.29 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.94 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| ADA | ENSG00000196839 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| VCAN | ENSG00000038427 | 2.22 | 8.14 | 1.14 | 2.92 | 0.00 | 6.77 | 8.11 | 4.42 | 1.29 | 4.78 | 0.00 | 1.36 | 2.14 | 0.00 | 0.59 | 1.94 | 10.92 | 7.08 | 1.23 | 2.70 | 1.72 | 0.56 | 0.61 | 5.47 | 0.00 | 10.66 | 3.79 | 0.00 | 0.20 | 0.00 | 3.55 | 0.00 | 0.00 |
| ANXA1 | ENSG00000135046 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 0.78 | 1.29 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OGN | ENSG00000106809 | 0.00 | 0.76 | 0.21 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.11 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| TNC | ENSG00000041982 | 1.11 | 3.05 | 1.24 | 2.55 | 0.00 | 4.19 | 2.70 | 3.31 | 0.52 | 1.99 | 0.00 | 1.36 | 0.71 | 1.47 | 0.59 | 1.39 | 3.58 | 3.65 | 1.23 | 1.96 | 1.15 | 0.00 | 0.41 | 1.56 | 1.72 | 6.40 | 2.17 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| TIMP1 | ENSG00000102265 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GLA | ENSG00000102393 | 0.00 | 0.51 | 0.62 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| PSAP | ENSG00000197746 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 0.94 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| HPX | ENSG00000110169 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 2.07 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.20 | 0.00 | 0.22 | 1.82 | 0.00 |
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