Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PLP1 | ENSG00000123560 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.47 | 0.20 | 1.11 | 0.75 | 0.86 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KCND3 | ENSG00000171385 | 1.11 | 0.51 | 0.62 | 1.09 | 0.00 | 2.90 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.81 | 0.00 | 0.74 | 0.00 | 0.28 | 2.64 | 1.50 | 0.00 | 1.23 | 0.00 | 0.00 | 0.81 | 1.56 | 0.00 | 6.40 | 2.17 | 0.00 | 0.41 | 0.00 | 0.44 | 1.82 | 0.00 |
| KCNJ10 | ENSG00000177807 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| MFSD4 | ENSG00000174514 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.75 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| TRPM5 | ENSG00000070985 | 0.00 | 0.76 | 0.83 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.56 | 1.69 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 2.37 | 1.36 | 0.69 | 0.20 | 2.48 | 2.00 | 0.00 | 1.25 |
| KCNA6 | ENSG00000151079 | 1.11 | 1.53 | 0.31 | 1.46 | 0.00 | 0.32 | 2.70 | 1.10 | 0.26 | 1.99 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.39 | 1.88 | 1.93 | 0.00 | 0.49 | 2.87 | 0.56 | 0.20 | 0.00 | 0.43 | 4.98 | 1.36 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| SLC7A7 | ENSG00000155465 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 1.56 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP10A | ENSG00000206190 | 0.00 | 4.07 | 1.03 | 4.38 | 0.00 | 5.48 | 2.70 | 3.31 | 1.03 | 3.78 | 0.00 | 0.27 | 2.49 | 0.00 | 0.59 | 2.22 | 2.45 | 9.44 | 0.00 | 1.23 | 2.30 | 0.00 | 0.00 | 6.25 | 0.43 | 2.37 | 4.88 | 0.00 | 0.00 | 0.83 | 3.77 | 0.00 | 0.00 |
| TRPM1 | ENSG00000134160 | 1.11 | 3.31 | 0.62 | 1.46 | 0.00 | 1.29 | 0.00 | 1.66 | 0.77 | 1.00 | 0.00 | 0.00 | 1.78 | 0.74 | 0.59 | 1.67 | 5.27 | 4.72 | 0.00 | 1.47 | 1.15 | 0.56 | 0.41 | 0.78 | 0.86 | 3.08 | 2.44 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| ATP8B4 | ENSG00000104043 | 0.00 | 3.05 | 0.52 | 1.46 | 0.00 | 0.97 | 0.00 | 1.66 | 1.80 | 2.39 | 0.00 | 0.27 | 0.36 | 0.74 | 0.59 | 0.00 | 4.14 | 4.72 | 1.23 | 0.98 | 1.15 | 0.00 | 0.41 | 2.34 | 0.43 | 8.06 | 2.71 | 0.00 | 0.00 | 0.00 | 3.55 | 0.00 | 1.25 |
| SLC47A2 | ENSG00000180638 | 1.11 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| OMG | ENSG00000126861 | 1.11 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ABCA9 | ENSG00000154258 | 0.00 | 3.05 | 1.45 | 0.73 | 0.00 | 2.26 | 0.00 | 1.10 | 0.77 | 1.79 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 3.39 | 6.01 | 0.00 | 1.72 | 0.57 | 0.56 | 0.61 | 2.34 | 1.29 | 3.32 | 1.36 | 0.00 | 0.20 | 0.00 | 3.55 | 3.64 | 0.00 |
| CEACAM7 | ENSG00000007306 | 0.00 | 1.27 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KCNK3 | ENSG00000171303 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 5.41 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.19 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC17A4 | ENSG00000146039 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 2.70 | 2.21 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.78 | 0.83 | 2.64 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.84 | 1.90 | 0.69 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| CACNA2D1 | ENSG00000153956 | 2.22 | 3.82 | 0.72 | 1.46 | 0.00 | 2.90 | 5.41 | 2.21 | 2.06 | 3.59 | 1.54 | 0.81 | 0.71 | 0.00 | 0.39 | 3.06 | 6.59 | 4.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 5.45 | 1.90 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 1.25 |
| SLC10A5 | ENSG00000253598 | 2.22 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.86 | 1.23 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| KCNV1 | ENSG00000164794 | 0.00 | 1.53 | 0.62 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 1.03 | 2.19 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 1.51 | 3.00 | 0.00 | 0.49 | 0.57 | 0.00 | 0.81 | 0.78 | 1.29 | 4.50 | 2.17 | 0.69 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| KCNK9 | ENSG00000169427 | 1.11 | 0.76 | 0.72 | 1.09 | 0.00 | 1.61 | 2.70 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 1.11 | 1.69 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 2.84 | 2.44 | 0.69 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
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