Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TMPRSS9 | ENSG00000178297 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 0.97 | 2.70 | 2.21 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.28 | 0.56 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LILRB5 | ENSG00000105609 | 1.11 | 1.53 | 0.62 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.80 | 1.54 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 1.51 | 3.43 | 0.00 | 0.25 | 0.00 | 0.56 | 1.22 | 3.91 | 1.29 | 3.79 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| SLC22A13 | ENSG00000172940 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GABRR3 | ENSG00000183185 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TMPRSS7 | ENSG00000176040 | 0.00 | 1.27 | 0.31 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 1.29 | 0.20 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 1.94 | 0.75 | 1.72 | 1.23 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADCY5 | ENSG00000173175 | 1.11 | 2.80 | 1.03 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 2.06 | 1.39 | 0.00 | 1.36 | 0.71 | 0.74 | 0.20 | 1.11 | 4.33 | 2.15 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CLDN18 | ENSG00000066405 | 0.00 | 0.25 | 0.21 | 1.09 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HTR3D | ENSG00000186090 | 1.11 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| HTR3C | ENSG00000178084 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.69 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.41 | 0.00 | 1.33 | 0.00 | 0.00 |
| HTR3E | ENSG00000186038 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 1.32 | 2.15 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SLC34A2 | ENSG00000157765 | 0.00 | 0.25 | 0.52 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.83 | 2.07 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 3.79 | 0.81 | 0.00 | 0.61 | 0.00 | 1.33 | 0.00 | 0.00 |
| GRID2 | ENSG00000152208 | 0.00 | 2.54 | 0.93 | 1.09 | 0.00 | 2.90 | 5.41 | 2.76 | 0.77 | 3.39 | 0.00 | 1.63 | 1.07 | 0.00 | 0.20 | 0.83 | 7.16 | 7.94 | 0.00 | 0.98 | 1.72 | 0.00 | 0.61 | 0.78 | 0.86 | 10.90 | 3.52 | 0.69 | 0.20 | 0.83 | 1.77 | 0.00 | 0.00 |
| ASIC5 | ENSG00000256394 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 1.94 | 2.70 | 0.55 | 0.77 | 1.39 | 0.00 | 0.27 | 1.07 | 0.00 | 0.39 | 0.28 | 1.13 | 2.15 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 1.90 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| GPM6A | ENSG00000150625 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.28 | 1.69 | 3.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC36A2 | ENSG00000186335 | 0.00 | 0.51 | 0.31 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.56 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 1.56 | 0.00 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC26A8 | ENSG00000112053 | 0.00 | 2.29 | 0.10 | 1.82 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.00 | 0.38 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 3.55 | 1.08 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| RHAG | ENSG00000112077 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.56 | 2.07 | 2.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.55 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC2A12 | ENSG00000146411 | 1.11 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.56 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC2A8 | ENSG00000136856 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| GLRA4 | ENSG00000188828 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 1.51 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
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