PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
CREB binding proteinENSG00000005339CREBBPchr16:3725054-3880726:-Tchem1227.16
farnesyltransferase, CAAX box, alphaENSG00000168522FNTAchr8:43034194-43085788:+Tbio13.8417
SUMO specific peptidase 6ENSG00000112701SENP6chr6:75601509-75718278:+Tbio27.3421
G protein-coupled bile acid receptor 1ENSG00000179921GPBAR1chr2:218259496-218263859:+Tchem141.137
kallikrein related peptidase 8ENSG00000129455KLK8chr19:50996007-51002711:-Tchem79.77
ATP binding cassette subfamily B member 11ENSG00000073734ABCB11chr2:168922938-169031322:-Tchem445.114
matrilin 3ENSG00000132031MATN3chr2:19992111-20012694:-Tbio92.7719
glutamate ionotropic receptor AMPA type subunit 2ENSG00000120251GRIA2chr4:157204182-157366075:+Tclin543.569
solute carrier family 5 member 3ENSG00000198743SLC5A3chr21:34073570-34106260:+Tbio81.6183
cathepsin ZENSG00000101160CTSZchr20:58995185-59007247:-Tchem56.7206
Wnt family member 3ENSG00000108379WNT3chr17:46762506-46833154:-Tchem78.9743
laminin subunit alpha 1ENSG00000101680LAMA1chr18:6941744-7117814:-Tbio79.9163
FKBP prolyl isomerase 10ENSG00000141756FKBP10chr17:41812680-41823217:+Tbio39.9107
ATP binding cassette subfamily A member 2ENSG00000107331ABCA2chr9:137007227-137028922:-Tbio98.4917
sulfotransferase family 1C member 2ENSG00000198203SULT1C2chr2:108288639-108309915:+Tbio13.7755
glycoprotein 2ENSG00000169347GP2chr16:20309572-20327808:-Tbio215.045
TNF superfamily member 15ENSG00000181634TNFSF15chr9:114784635-114806126:-Tbio169.224
integrin subunit alpha 1ENSG00000213949ITGA1chr5:52787896-52959210:+Tbio126.132
lymphotoxin betaENSG00000227507LTBchr6:31580525-31582522:-Tbio115.499
ADAM metallopeptidase with thrombospondin type 1 motif 13ENSG00000160323ADAMTS13chr9:133414358-133459402:+Tbio1273.38

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