PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| collagen type XXII alpha 1 chain | ENSG00000169436 | COL22A1 | chr8:138588235-138914006:- | Tdark | 4.875 |
| bone marrow stromal cell antigen 2 | ENSG00000130303 | BST2 | chr19:17402939-17405648:- | Tbio | 413.18 |
| vasoactive intestinal peptide receptor 2 | ENSG00000106018 | VIPR2 | chr7:159028175-159144957:- | Tchem | 99.2597 |
| RNA binding motif protein 5 | ENSG00000003756 | RBM5 | chr3:50088908-50119021:+ | Tbio | 82.4877 |
| proprotein convertase subtilisin/kexin type 7 | ENSG00000160613 | PCSK7 | chr11:117204337-117232525:- | Tchem | 107.974 |
| arylsulfatase B | ENSG00000113273 | ARSB | chr5:78777209-78986087:- | Tbio | 354.355 |
| nuclear receptor subfamily 0 group B member 2 | ENSG00000131910 | NR0B2 | chr1:26911489-26913966:- | Tbio | 250.135 |
| proteinase 3 | ENSG00000196415 | PRTN3 | chr19:840960-848175:+ | Tchem | 1796.63 |
| solute carrier family 39 member 1 | ENSG00000143570 | SLC39A1 | chr1:153959099-153968184:- | Tbio | 51.5961 |
| collagen type IV alpha 2 chain | ENSG00000134871 | COL4A2 | chr13:110305812-110513027:+ | Tbio | 57.5211 |
| MAS related GPR family member F | ENSG00000172935 | MRGPRF | chr11:69004395-69013409:- | Tdark | 275.074 |
| matrix Gla protein | ENSG00000111341 | MGP | chr12:14881181-14885926:- | Tbio | 347.223 |
| solute carrier family 22 member 1 | ENSG00000175003 | SLC22A1 | chr6:160121789-160158718:+ | Tchem | 484.617 |
| integrin subunit alpha 9 | ENSG00000144668 | ITGA9 | chr3:37452115-37823514:+ | Tbio | 74.5695 |
| amine oxidase copper containing 3 | ENSG00000131471 | AOC3 | chr17:42851184-42858130:+ | Tchem | 216.786 |
| BOC cell adhesion associated, oncogene regulated | ENSG00000144857 | BOC | chr3:113211003-113287459:+ | Tbio | 85.0909 |
| protein tyrosine phosphatase non-receptor type 12 | ENSG00000127947 | PTPN12 | chr7:77537275-77640071:+ | Tchem | 66.7675 |
| tankyrase | ENSG00000173273 | TNKS | chr8:9555914-9782346:+ | Tchem | 574.491 |
| olfactomedin 4 | ENSG00000102837 | OLFM4 | chr13:53028759-53052057:+ | Tbio | 149.787 |
| anosmin 1 | ENSG00000011201 | ANOS1 | chrX:8528874-8732187:- | Tbio | 224.482 |
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