PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
collagen type XXII alpha 1 chainENSG00000169436COL22A1chr8:138588235-138914006:-Tdark4.875
bone marrow stromal cell antigen 2ENSG00000130303BST2chr19:17402939-17405648:-Tbio413.18
vasoactive intestinal peptide receptor 2ENSG00000106018VIPR2chr7:159028175-159144957:-Tchem99.2597
RNA binding motif protein 5ENSG00000003756RBM5chr3:50088908-50119021:+Tbio82.4877
proprotein convertase subtilisin/kexin type 7ENSG00000160613PCSK7chr11:117204337-117232525:-Tchem107.974
arylsulfatase BENSG00000113273ARSBchr5:78777209-78986087:-Tbio354.355
nuclear receptor subfamily 0 group B member 2ENSG00000131910NR0B2chr1:26911489-26913966:-Tbio250.135
proteinase 3ENSG00000196415PRTN3chr19:840960-848175:+Tchem1796.63
solute carrier family 39 member 1ENSG00000143570SLC39A1chr1:153959099-153968184:-Tbio51.5961
collagen type IV alpha 2 chainENSG00000134871COL4A2chr13:110305812-110513027:+Tbio57.5211
MAS related GPR family member FENSG00000172935MRGPRFchr11:69004395-69013409:-Tdark275.074
matrix Gla proteinENSG00000111341MGPchr12:14881181-14885926:-Tbio347.223
solute carrier family 22 member 1ENSG00000175003SLC22A1chr6:160121789-160158718:+Tchem484.617
integrin subunit alpha 9ENSG00000144668ITGA9chr3:37452115-37823514:+Tbio74.5695
amine oxidase copper containing 3ENSG00000131471AOC3chr17:42851184-42858130:+Tchem216.786
BOC cell adhesion associated, oncogene regulatedENSG00000144857BOCchr3:113211003-113287459:+Tbio85.0909
protein tyrosine phosphatase non-receptor type 12ENSG00000127947PTPN12chr7:77537275-77640071:+Tchem66.7675
tankyraseENSG00000173273TNKSchr8:9555914-9782346:+Tchem574.491
olfactomedin 4ENSG00000102837OLFM4chr13:53028759-53052057:+Tbio149.787
anosmin 1ENSG00000011201ANOS1chrX:8528874-8732187:-Tbio224.482

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