PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
carboxypeptidase QENSG00000104324CPQchr8:96645227-97149654:+Tbio1268.04
endoplasmic reticulum to nucleus signaling 2ENSG00000134398ERN2chr16:23690326-23713500:-Tbio7.57063
prostaglandin D2 receptor 2ENSG00000183134PTGDR2chr11:60850940-60855971:-Tchem184.794
microtubule affinity regulating kinase 2ENSG00000072518MARK2chr11:63838928-63911019:+Tchem171.112
frizzled class receptor 7ENSG00000155760FZD7chr2:202034587-202038445:+Tbio36.6956
nogginENSG00000183691NOGchr17:56593699-56595590:+Tbio295.241
DOT1 like histone lysine methyltransferaseENSG00000104885DOT1Lchr19:2164149-2232578:+Tchem102.682
odorant binding protein 2AENSG00000122136OBP2Achr9:135546139-135549969:+Tdark88.45
fibroblast growth factor 8ENSG00000107831FGF8chr10:101770130-101780369:-Tbio221.703
ATP binding cassette subfamily D member 2ENSG00000173208ABCD2chr12:39550033-39619751:-Tbio176.273
troponin T2, cardiac typeENSG00000118194TNNT2chr1:201359008-201377762:-Tbio2669.84
glycoprotein nmbENSG00000136235GPNMBchr7:23235967-23275108:+Tbio74.2289
growth factor, augmenter of liver regenerationENSG00000127554GFERchr16:1984207-1987749:+Tchem173.787
TNF superfamily member 12ENSG00000239697TNFSF12chr17:7548891-7557890:+Tbio276.429
chemokine like factorENSG00000217555CKLFchr16:66552563-66566251:+Tbio179.868
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3ENSG00000110719TCIRG1chr11:68039016-68050895:+Tbio122.424
transcobalamin 2ENSG00000185339TCN2chr22:30606838-30627278:+Tbio392.673
fibroblast growth factor 4ENSG00000075388FGF4chr11:69771016-69775403:-Tbio252.757
pygopus family PHD finger 2ENSG00000163348PYGO2chr1:154957026-154963853:-Tbio28.2676
solute carrier family 22 member 6ENSG00000197901SLC22A6chr11:62936385-62984983:-Tclin185.473

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