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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
UDP glycosyltransferase 8	ENSG00000174607	UGT8	chr4:114598455-114678224:+	Tbio	86.7392
colony stimulating factor 1 receptor	ENSG00000182578	CSF1R	chr5:150053291-150113372:-	Tclin	552.495
kallikrein B1	ENSG00000164344	KLKB1	chr4:186208979-186258471:+	Tclin	111.157
solute carrier family 12 member 5	ENSG00000124140	SLC12A5	chr20:46021690-46060152:+	Tbio	155.755
calcium voltage-gated channel subunit alpha1 H	ENSG00000196557	CACNA1H	chr16:1153241-1221771:+	Tclin	127.864
caspase 6	ENSG00000138794	CASP6	chr4:109688622-109703583:-	Tchem	233.287
C-C motif chemokine ligand 7	ENSG00000108688	CCL7	chr17:34270221-34272242:+	Tbio	292.954
collagen type V alpha 3 chain	ENSG00000080573	COL5A3	chr19:9959561-10010471:-	Tbio	13.2448
protein S	ENSG00000184500	PROS1	chr3:93873033-93974066:-	Tbio	167.855
deoxycytidine kinase	ENSG00000156136	DCK	chr4:70992538-71030914:+	Tchem	338.66
insulin like growth factor binding protein 4	ENSG00000141753	IGFBP4	chr17:40443461-40457731:+	Tchem	210.569
TUB bipartite transcription factor	ENSG00000166402	TUB	chr11:8019244-8106112:+	Tbio	180.765
aldo-keto reductase family 1 member C4	ENSG00000198610	AKR1C4	chr10:5195462-5218949:+	Tbio	273.91
mannose phosphate isomerase	ENSG00000178802	MPI	chr15:74890005-74902219:+	Tchem	127.242
enamelin	ENSG00000132464	ENAM	chr4:70628744-70686816:+	Tbio	116.605
solute carrier family 6 member 4	ENSG00000108576	SLC6A4	chr17:30194319-30236002:-	Tclin	4693.4
sodium channel epithelial 1 subunit gamma	ENSG00000166828	SCNN1G	chr16:23182715-23216883:+	Tclin	132.381
p21 (RAC1) activated kinase 4	ENSG00000130669	PAK4	chr19:39125770-39182816:+	Tchem	89.4274
PHD finger protein 24	ENSG00000122733	PHF24	chr9:34957608-34982544:+	Tdark	0
phosphodiesterase 4B	ENSG00000184588	PDE4B	chr1:65792514-66374579:+	Tclin	119.841

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