PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
adenylate cyclase 1ENSG00000164742ADCY1chr7:45574140-45723116:+Tchem232.358
retinol binding protein 1ENSG00000114115RBP1chr3:139517434-139539829:-Tbio173.903
death inducer-obliterator 1ENSG00000101191DIDO1chr20:62877738-62937952:-Tbio11.3423
hyaluronan binding protein 2ENSG00000148702HABP2chr10:113550837-113589602:+Tbio169.696
polo like kinase 2ENSG00000145632PLK2chr5:58453982-58460260:-Tchem110.278
sodium voltage-gated channel alpha subunit 4ENSG00000007314SCN4Achr17:63938554-63972918:-Tclin342.585
microsomal triglyceride transfer proteinENSG00000138823MTTPchr4:99563761-99623999:+Tclin232.117
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSG00000196296ATP2A1chr16:28878405-28904509:+Tchem131.087
potassium two pore domain channel subfamily K member 3ENSG00000171303KCNK3chr2:26692690-26733420:+Tclin4098.25
jumonji and AT-rich interaction domain containing 2ENSG00000008083JARID2chr6:15246296-15522040:+Tbio39.8746
adrenoceptor alpha 1DENSG00000171873ADRA1Dchr20:4220631-4249074:-Tclin2944.59
growth differentiation factor 6ENSG00000156466GDF6chr8:96142330-96160792:-Tbio329.925
cathepsin VENSG00000136943CTSVchr9:97029679-97039643:-Tchem38.3441
aryl hydrocarbon receptor interacting proteinENSG00000110711AIPchr11:67483041-67491103:+Tbio133.906
surfactant protein BENSG00000168878SFTPBchr2:85657314-85668741:-Tbio656.741
solute carrier family 25 member 4ENSG00000151729SLC25A4chr4:185143241-185150382:+Tbio112.282
aldo-keto reductase family 1 member BENSG00000085662AKR1B1chr7:134442350-134459284:-Tclin343.956
serum amyloid A2ENSG00000134339SAA2chr11:18239223-18248643:-Tbio51.5336
peptidylprolyl cis/trans isomerase, NIMA-interacting 1ENSG00000127445PIN1chr19:9835257-9849682:+Tchem562.898
acid phosphatase 5, tartrate resistantENSG00000102575ACP5chr19:11574660-11579008:-Tbio80.4505

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