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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
advanced glycosylation end-product specific receptor	ENSG00000204305	AGER	chr6:32180968-32184324:-	Tchem	748.989
doublecortin like kinase 1	ENSG00000133083	DCLK1	chr13:35768652-36131306:-	Tchem	61.0252
formyl peptide receptor 2	ENSG00000171049	FPR2	chr19:51752026-51770526:+	Tchem	221.02
spermine synthase	ENSG00000102172	SMS	chrX:21940573-21994835:+	Tchem	53.5095
collagen type XIV alpha 1 chain	ENSG00000187955	COL14A1	chr8:120059780-120372036:+	Tbio	37.0009
RNA binding motif protein 10	ENSG00000182872	RBM10	chrX:47144869-47186813:+	Tbio	23.2886
leucine rich repeat containing 4	ENSG00000128594	LRRC4	chr7:128027071-128032107:-	Tbio	23.3758
mitogen-activated protein kinase 3	ENSG00000102882	MAPK3	chr16:30114105-30123506:-	Tchem	1169.27
C-C motif chemokine receptor 1	ENSG00000163823	CCR1	chr3:46201709-46208396:-	Tchem	269.115
sterol carrier protein 2	ENSG00000116171	SCP2	chr1:52927229-53051703:+	Tchem	173.044
insulin like growth factor 2 receptor	ENSG00000197081	IGF2R	chr6:159969099-160113507:+	Tchem	329.709
cyclin G associated kinase	ENSG00000178950	GAK	chr4:849276-932373:-	Tchem	46.5132
pleckstrin	ENSG00000115956	PLEK	chr2:68365173-68397453:+	Tbio	376.435
napsin A aspartic peptidase	ENSG00000131400	NAPSA	chr19:50358477-50365830:-	Tbio	82.9345
seizure related 6 homolog like 2	ENSG00000174938	SEZ6L2	chr16:29871159-29899547:-	Tbio	7.21978
catechol-O-methyltransferase	ENSG00000093010	COMT	chr22:19941607-19969975:+	Tclin	3771.85
fibulin 5	ENSG00000140092	FBLN5	chr14:91869412-91947987:-	Tbio	113.827
glutathione peroxidase 8 (putative)	ENSG00000164294	GPX8	chr5:55160118-55167071:+	Tbio	6.12811
HtrA serine peptidase 1	ENSG00000166033	HTRA1	chr10:122461525-122514908:+	Tbio	319.6
kallikrein related peptidase 15	ENSG00000174562	KLK15	chr19:50825289-50837213:-	Tbio	33.0548

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