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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
ribosomal protein S27	ENSG00000177954	RPS27	chr1:153990759-153992150:+	Tchem	34.2335
formyl peptide receptor 1	ENSG00000171051	FPR1	chr19:51745172-51804110:-	Tchem	2628.74
cartilage intermediate layer protein 2	ENSG00000160161	CILP2	chr19:19538248-19546659:+	Tbio	7.0375
UDP glucuronosyltransferase family 2 member B15	ENSG00000196620	UGT2B15	chr4:68537413-68670628:-	Tbio	99.41
EPH receptor B4	ENSG00000196411	EPHB4	chr7:100802565-100827521:-	Tchem	156.005
solute carrier family 9 member A1	ENSG00000090020	SLC9A1	chr1:27098815-27166981:-	Tchem	517.361
casein kinase 2 alpha 1	ENSG00000101266	CSNK2A1	chr20:473591-543821:-	Tchem	369.759
solute carrier family 22 member 3	ENSG00000146477	SLC22A3	chr6:160348268-160452581:+	Tchem	85.4092
MLLT6, PHD finger containing	ENSG00000275023	MLLT6	chr17:38705542-38729803:+	Tdark	10.313
relaxin family peptide receptor 1	ENSG00000171509	RXFP1	chr4:158315311-158653372:+	Tbio	114.409
dermatopontin	ENSG00000143196	DPT	chr1:168695459-168729264:-	Tbio	32.304
cholinergic receptor nicotinic alpha 2 subunit	ENSG00000120903	CHRNA2	chr8:27459762-27479883:-	Tchem	33.1524
chloride voltage-gated channel 2	ENSG00000114859	CLCN2	chr3:184346185-184361651:-	Tclin	174.393
aquaporin 9	ENSG00000103569	AQP9	chr15:58138169-58185911:+	Tbio	124.16
aldehyde dehydrogenase 1 family member A2	ENSG00000128918	ALDH1A2	chr15:57953424-58497866:-	Tbio	60.507
betacellulin	ENSG00000174808	BTC	chr4:74744759-74794686:-	Tbio	69.3315
protein tyrosine phosphatase non-receptor type 3	ENSG00000070159	PTPN3	chr9:109375466-109498313:-	Tbio	30.4764
P2Y receptor family member 8	ENSG00000182162	P2RY8	chrX:1462572-1537107:-	Tbio	12.5078
complement component 4 binding protein alpha	ENSG00000123838	C4BPA	chr1:207104262-207144972:+	Tbio	463.052
C-C motif chemokine receptor 6	ENSG00000112486	CCR6	chr6:167111807-167139696:+	Tchem	250.176

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