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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
maltase-glucoamylase	ENSG00000257335	MGAM	chr7:141907813-142106747:+	Tclin	81.9413
glutamate ionotropic receptor NMDA type subunit 2D	ENSG00000105464	GRIN2D	chr19:48394875-48444931:+	Tclin	48.1863
hemopexin	ENSG00000110169	HPX	chr11:6431049-6442617:-	Tbio	351.823
toll like receptor 6	ENSG00000174130	TLR6	chr4:38823715-38856817:-	Tbio	103.86
secreted LY6/PLAUR domain containing 1	ENSG00000126233	SLURP1	chr8:142740944-142742411:-	Tbio	202.831
p21 (RAC1) activated kinase 5	ENSG00000101349	PAK7	chr20:9537389-9839041:-	Tchem	25.4613
nuclear receptor subfamily 1 group I member 3	ENSG00000143257	NR1I3	chr1:161229666-161238302:-	Tchem	341.703
microfibril associated protein 4	ENSG00000166482	MFAP4	chr17:19383442-19387240:-	Tbio	18.081
BMX non-receptor tyrosine kinase	ENSG00000102010	BMX	chrX:15464246-15556529:+	Tchem	106.779
olfactomedin like 2B	ENSG00000162745	OLFML2B	chr1:161983192-162023854:-	Tdark	0.125
transcobalamin 1	ENSG00000134827	TCN1	chr11:59852800-59866575:-	Tbio	312.676
adenosine A3 receptor	ENSG00000121933	ADORA3	chr1:111483348-111563962:-	Tchem	270.994
caspase 10	ENSG00000003400	CASP10	chr2:201182881-201229406:+	Tchem	145.701
ADAM metallopeptidase domain 15	ENSG00000143537	ADAM15	chr1:155050566-155062775:+	Tbio	78.7389
transient receptor potential cation channel subfamily A member 1	ENSG00000104321	TRPA1	chr8:72019917-72075617:-	Tclin	407.964
SP140 nuclear body protein like	ENSG00000185404	SP140L	chr2:230327184-230403732:+	Tdark	0.309524
paraoxonase 2	ENSG00000105854	PON2	chr7:95404863-95435329:-	Tbio	176.865
tyrosine kinase non receptor 2	ENSG00000061938	TNK2	chr3:195863364-195911945:-	Tchem	97.0424
PYD and CARD domain containing	ENSG00000103490	PYCARD	chr16:31201485-31203450:-	Tbio	657.135
inner mitochondrial membrane peptidase subunit 2	ENSG00000184903	IMMP2L	chr7:110663051-111562517:-	Tbio	11.3067

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