PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
major histocompatibility complex, class II, DP beta 1ENSG00000223865HLA-DPB1chr6:33075926-33087201:+Tbio143.212
secretoglobin family 3A member 1ENSG00000161055SCGB3A1chr5:180590103-180591540:-Tbio34.45
O-GlcNAcaseENSG00000198408MGEA5chr10:101784443-101818465:-Tchem2008.03
sphingomyelin phosphodiesterase 1ENSG00000166311SMPD1chr11:6390431-6394998:+Tbio369.431
Fc fragment of IgG receptor IIbENSG00000072694FCGR2Bchr1:161581311-161678654:+Tbio315.634
major histocompatibility complex, class II, DR alphaENSG00000204287HLA-DRAchr6:32439842-32445046:+Tbio126.773
chromobox 1ENSG00000108468CBX1chr17:48070052-48101521:-Tbio104.312
potassium voltage-gated channel subfamily D member 2ENSG00000184408KCND2chr7:120273668-120750331:+Tclin110.272
calcium sensing receptorENSG00000036828CASRchr3:122183683-122286503:+Tclin875.21
solute carrier family 4 member 3ENSG00000114923SLC4A3chr2:219627327-219641980:+Tdark378.445
receptor tyrosine kinase like orphan receptor 2ENSG00000169071ROR2chr9:91563091-91950162:-Tbio131.178
phospholipase C epsilon 1ENSG00000138193PLCE1chr10:93993989-94332823:+Tbio105.133
neuregulin 3ENSG00000185737NRG3chr10:81875314-82987179:+Tbio37.6443
serpin family F member 2ENSG00000167711SERPINF2chr17:1742836-1755268:+Tbio787.24
mitogen-activated protein kinase kinase 6ENSG00000108984MAP2K6chr17:69414698-69543331:+Tchem95.3321
proteasome 20S subunit beta 6ENSG00000142507PSMB6chr17:4796144-4798503:+Tbio5.4254
solute carrier family 25 member 37ENSG00000147454SLC25A37chr8:23528805-23575463:+Tbio7.80593
cytochrome P450 family 4 subfamily F member 3ENSG00000186529CYP4F3chr19:15615617-15662825:+Tbio4812.61
peptidylprolyl isomerase like 2ENSG00000100023PPIL2chr22:21652270-21700015:+Tbio11.7595
protein tyrosine phosphatase non-receptor type 4ENSG00000088179PTPN4chr2:119759631-119983818:+Tbio1289.76

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