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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
cathepsin B	ENSG00000164733	CTSB	chr8:11842524-11869448:-	Tchem	2020.79
vascular endothelial growth factor A	ENSG00000112715	VEGFA	chr6:43770184-43786487:+	Tclin	20585.3
stearoyl-CoA desaturase	ENSG00000099194	SCD	chr10:100347124-100364834:+	Tchem	276.564
kinase insert domain receptor	ENSG00000128052	KDR	chr4:55078477-55125589:-	Tclin	2715.46
integrin subunit beta 1	ENSG00000150093	ITGB1	chr10:32900319-33005792:-	Tclin	1599.89
solute carrier family 2 member 1	ENSG00000117394	SLC2A1	chr1:42925375-42959173:-	Tchem	1866.24
epidermal growth factor	ENSG00000138798	EGF	chr4:109912884-110012266:+	Tbio	3606.99
pyruvate dehydrogenase kinase 1	ENSG00000152256	PDK1	chr2:172555373-172608669:+	Tchem	349.86
origin recognition complex subunit 1	ENSG00000085840	ORC1	chr1:52372829-52404459:-	Tbio	66.4877
adenosine deaminase	ENSG00000196839	ADA	chr20:44619522-44652233:-	Tclin	2805.47
insulin receptor	ENSG00000171105	INSR	chr19:7112255-7294034:-	Tclin	2867.06
Pim-1 proto-oncogene, serine/threonine kinase	ENSG00000137193	PIM1	chr6:37170203-37175426:+	Tchem	475.304
signal transducer and activator of transcription 5B	ENSG00000173757	STAT5B	chr17:42199168-42276707:-	Tchem	243.11
gastrin	ENSG00000184502	GAST	chr17:41712326-41715969:+	Tbio	5732.72
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	ENSG00000080503	SMARCA2	chr9:2015219-2193624:+	Tchem	114.339
platelet derived growth factor receptor beta	ENSG00000113721	PDGFRB	chr5:150113837-150155872:-	Tclin	947.179
Fas ligand	ENSG00000117560	FASLG	chr1:172659018-172666874:+	Tbio	2932.52
nuclear receptor subfamily 3 group C member 1	ENSG00000113580	NR3C1	chr5:143277931-143435512:-	Tclin	3774.46
signal transducer and activator of transcription 3	ENSG00000168610	STAT3	chr17:42313324-42388568:-	Tchem	3667.37
nuclear factor kappa B subunit 2	ENSG00000077150	NFKB2	chr10:102394110-102402529:+	Tchem	966.222

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