PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
calcium voltage-gated channel subunit alpha1 BENSG00000148408CACNA1Bchr9:137877789-138124624:+Tclin224.91
cytochrome P450 family 26 subfamily B member 1ENSG00000003137CYP26B1chr2:72129238-72148038:-Tchem44.0433
PR/SET domain 11ENSG00000019485PRDM11chr11:45095806-45235124:+Tbio0.166667
megakaryocyte-associated tyrosine kinaseENSG00000007264MATKchr19:3777970-3802129:-Tbio576.602
nuclear receptor subfamily 2 group E member 1ENSG00000112333NR2E1chr6:108166058-108188809:+Tbio21.5826
tyrosine kinase with immunoglobulin like and EGF like domains 1ENSG00000066056TIE1chr1:43300993-43323108:+Tchem82.5491
integrin subunit beta 2ENSG00000160255ITGB2chr21:44885953-44931989:-Tclin1246.23
proteasome 20S subunit beta 2ENSG00000126067PSMB2chr1:35599544-35641844:-Tclin2.25014
glycoprotein Ib platelet subunit alphaENSG00000185245GP1BAchr17:4932297-4935030:+Tbio608.444
growth differentiation factor 10ENSG00000266524GDF10chr10:47300386-47313547:+Tbio241.203
zinc finger CW-type and PWWP domain containing 1ENSG00000078487ZCWPW1chr7:100400826-100428992:-Tdark5.56127
ornithine decarboxylase 1ENSG00000115758ODC1chr2:10439968-10448504:-Tclin1798.36
caspase 14ENSG00000105141CASP14chr19:15049384-15058293:+Tbio75.3131
dual specificity phosphatase 15ENSG00000149599DUSP15chr20:31847637-31870747:-Tbio6.73333
phospholipid transfer proteinENSG00000100979PLTPchr20:45898621-45912155:-Tbio203.991
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1ENSG00000152377SPOCK1chr5:136975298-137598379:-Tbio33.7769
natriuretic peptide receptor 2ENSG00000159899NPR2chr9:35792154-35809732:+Tbio295.249
solute carrier family 12 member 2ENSG00000064651SLC12A2chr5:128083766-128189688:+Tclin279.957
Wnt family member 7AENSG00000154764WNT7Achr3:13816258-13880121:-Tbio91.1604
complement C4B (Chido blood group)ENSG00000224389C4Bchr6:32014762-32035418:+Tbio603.591

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