PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
C-type lectin domain containing 10AENSG00000132514CLEC10Achr17:7074537-7080307:-Tbio159.827
solute carrier family 15 member 1ENSG00000088386SLC15A1chr13:98683801-98752654:-Tchem359.325
C-C motif chemokine ligand 11ENSG00000172156CCL11chr17:34285668-34288334:+Tbio204.732
leukotriene B4 receptor 2ENSG00000213906LTB4R2chr14:24305734-24312053:+Tbio61.5194
jumonji domain containing 1CENSG00000171988JMJD1Cchr10:63167221-63521850:-Tbio14.9804
transient receptor potential cation channel subfamily V member 6ENSG00000165125TRPV6chr7:142871203-142885762:-Tchem184.431
mitogen-activated protein kinase 10ENSG00000109339MAPK10chr4:86015123-86594131:-Tchem84.393
pyruvate dehydrogenase kinase 4ENSG00000004799PDK4chr7:95583499-95596491:-Tbio92.1062
purinergic receptor P2X 2ENSG00000187848P2RX2chr12:132618780-132622386:+Tbio124.706
proteasome 20S subunit beta 3ENSG00000277791PSMB3chr17:38752736-38764231:+Tdark6.38618
TNF superfamily member 14ENSG00000125735TNFSF14chr19:6661253-6670588:-Tbio67.2476
transmembrane serine protease 6ENSG00000187045TMPRSS6chr22:37065436-37109563:-Tchem129.076
adhesion G protein-coupled receptor V1ENSG00000164199ADGRV1chr5:90529344-91164221:+Tbio120.173
mitogen-activated protein kinase kinase kinase kinase 4ENSG00000071054MAP4K4chr2:101696850-101894689:+Tchem52.168
complement factor DENSG00000197766CFDchr19:859643-863630:+Tchem239.604
major facilitator superfamily domain containing 4AENSG00000174514MFSD4chr1:205568885-205602918:+Tdark0.333333
proteasome 20S subunit alpha 5ENSG00000143106PSMA5chr1:109399031-109426427:-Tbio11.2014
mitogen-activated protein kinase kinase kinase 1ENSG00000095015MAP3K1chr5:56815574-56896152:+Tbio172.345
UDP-galactose-4-epimeraseENSG00000117308GALEchr1:23795599-23800804:-Tchem110.683
RELT TNF receptorENSG00000054967RELTchr11:73376264-73397474:+Tbio7.56667

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