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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
coagulation factor IX	ENSG00000101981	F9	chrX:139530758-139563458:+	Tchem	3413.19
dipeptidase 1	ENSG00000015413	DPEP1	chr16:89613308-89638456:+	Tclin	173.322
bromodomain adjacent to zinc finger domain 1A	ENSG00000198604	BAZ1A	chr14:34752731-34875647:-	Tbio	21.1024
glycoprotein A33	ENSG00000143167	GPA33	chr1:167052836-167166479:-	Tbio	100.094
solute carrier family 30 member 8	ENSG00000164756	SLC30A8	chr8:116950273-117176714:+	Tbio	165.925
ubiquitin specific peptidase 9 X-linked	ENSG00000124486	USP9X	chrX:41085635-41236579:+	Tbio	61.0385
CD200 molecule	ENSG00000091972	CD200	chr3:112332347-112362812:+	Tbio	194.33
MER proto-oncogene, tyrosine kinase	ENSG00000153208	MERTK	chr2:111898479-112029561:+	Tchem	118.519
proline rich membrane anchor 1	ENSG00000175785	PRIMA1	chr14:93718298-93788481:-	Tbio	175.641
collagen type IV alpha 3 chain	ENSG00000169031	COL4A3	chr2:227164565-227314792:+	Tbio	143.373
galectin 3	ENSG00000131981	LGALS3	chr14:55124110-55145413:+	Tchem	642.079
lipase E, hormone sensitive type	ENSG00000079435	LIPE	chr19:42401507-42427426:-	Tchem	308.986
phospholipase A2 receptor 1	ENSG00000153246	PLA2R1	chr2:159932006-160062610:-	Tbio	147.321
cystatin F	ENSG00000077984	CST7	chr20:24949230-24959928:+	Tbio	348.888
pancreatic polypeptide	ENSG00000108849	PPY	chr17:43940804-43942468:-	Tbio	611.942
serpin family F member 1	ENSG00000132386	SERPINF1	chr17:1761959-1777574:+	Tbio	244.249
proteasome 20S subunit alpha 4	ENSG00000041357	PSMA4	chr15:78540405-78552419:+	Tbio	14.6992
sex hormone binding globulin	ENSG00000129214	SHBG	chr17:7613946-7633383:+	Tchem	4044.9
serine peptidase inhibitor, Kunitz type 2	ENSG00000167642	SPINT2	chr19:38244035-38292614:+	Tbio	101.692
regenerating family member 4	ENSG00000134193	REG4	chr1:119794018-119811660:-	Tbio	106.048

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