PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
hydroxysteroid 17-beta dehydrogenase 10ENSG00000072506HSD17B10chrX:53431258-53434373:-Tbio148.448
solute carrier organic anion transporter family member 1B1ENSG00000134538SLCO1B1chr12:21131202-21239246:+Tchem531.885
leptinENSG00000174697LEPchr7:128241284-128257628:+Tbio6432.76
activin A receptor type 1ENSG00000115170ACVR1chr2:157736444-157875862:-Tchem178.93
fatty acid amide hydrolaseENSG00000117480FAAHchr1:46394265-46413848:+Tchem479.245
deoxyuridine triphosphataseENSG00000128951DUTchr15:48331011-48343373:+Tchem48.0834
atypical chemokine receptor 1 (Duffy blood group)ENSG00000213088ACKR1chr1:159203307-159206500:+Tbio409.046
serpin family A member 6ENSG00000170099SERPINA6chr14:94304248-94323394:-Tchem834.588
X-C motif chemokine ligand 1ENSG00000143184XCL1chr1:168576473-168582077:+Tbio107.565
transporter 2, ATP binding cassette subfamily B memberENSG00000204267TAP2chr6:32821833-32838780:-Tbio295.697
protein kinase C gammaENSG00000126583PRKCGchr19:53879190-53907652:+Tchem175.326
interleukin 1 receptor associated kinase 2ENSG00000134070IRAK2chr3:10164865-10243743:+Tbio23.4412
solute carrier family 31 member 1ENSG00000136868SLC31A1chr9:113221562-113264492:+Tbio185.646
dihydroorotate dehydrogenase (quinone)ENSG00000102967DHODHchr16:72008588-72027664:+Tclin117.262
Parkinsonism associated deglycaseENSG00000116288PARK7chr1:7954291-7985505:+Tbio581.091
aquaporin 1 (Colton blood group)ENSG00000240583AQP1chr7:30911855-30925516:+Tbio1078.46
mitogen-activated protein kinase kinase kinase 20ENSG00000091436pkchr2:173075435-173268010:+Tchem171.016
carboxypeptidase DENSG00000108582CPDchr17:30378905-30469989:+Tbio58.1293
retinoic acid receptor gammaENSG00000172819RARGchr12:53210567-53232980:-Tclin165.983
cardiotrophin 1ENSG00000150281CTF1chr16:30896607-30903560:+Tbio423.654

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