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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
calpain 1	ENSG00000014216	CAPN1	chr11:65180566-65212006:+	Tchem	233.962
cytochrome P450 family 2 subfamily W member 1	ENSG00000073067	CYP2W1	chr7:983199-989640:+	Tbio	32.0022
integrin subunit alpha 2b	ENSG00000005961	ITGA2B	chr17:44372180-44389505:-	Tclin	2637.82
cysteinyl leukotriene receptor 1	ENSG00000173198	CYSLTR1	chrX:78271464-78327691:-	Tclin	277.496
ERCC excision repair 5, endonuclease	ENSG00000134899	ERCC5	chr13:102844844-102876001:+	Tchem	283.754
IgA inducing protein	ENSG00000182700	IGIP	chr5:140125935-140129392:+	Tdark	1.5
phospholipase C gamma 1	ENSG00000124181	PLCG1	chr20:41136960-41196801:+	Tchem	448.156
aldehyde dehydrogenase 1 family member A3	ENSG00000184254	ALDH1A3	chr15:100877714-100916626:+	Tbio	61.4629
EPH receptor B6	ENSG00000106123	EPHB6	chr7:142855061-142871094:+	Tchem	44.3415
G protein-coupled receptor 3	ENSG00000181773	GPR3	chr1:27392644-27395814:+	Tbio	62.7368
dickkopf WNT signaling pathway inhibitor 4	ENSG00000104371	DKK4	chr8:42374068-42377232:-	Tbio	26.8639
eukaryotic elongation factor 2 lysine methyltransferase	ENSG00000118894	EEF2KMT	chr16:5084304-5097808:-	Tdark	0.666667
interferon induced protein with tetratricopeptide repeats 1	ENSG00000185745	IFIT1	chr10:89392546-89406486:+	Tbio	472.514
sulfotransferase family 1E member 1	ENSG00000109193	SULT1E1	chr4:69810780-69860152:-	Tchem	160.361
bromodomain containing 8	ENSG00000112983	BRD8	chr5:138139766-138178986:-	Tbio	29.0088
TNF receptor superfamily member 14	ENSG00000157873	TNFRSF14	chr1:2555639-2565382:+	Tbio	160.487
frizzled class receptor 5	ENSG00000163251	FZD5	chr2:207762586-207769563:-	Tbio	24.8467
solute carrier family 2 member 2	ENSG00000163581	SLC2A2	chr3:170996348-171026750:-	Tchem	297.424
UDP glucuronosyltransferase family 1 member A1	ENSG00000241635	UGT1A1	chr2:233760248-233773299:+	Tbio	1317.79
FES proto-oncogene, tyrosine kinase	ENSG00000182511	FES	chr15:90883695-90895776:+	Tchem	40.15

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