PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
PKHD1 ciliary IPT domain containing fibrocystin/polyductinENSG00000170927PKHD1chr6:51615300-52087625:-Tbio253.464
motilinENSG00000096395MLNchr6:33794673-33804011:-Tbio509.681
ATPase copper transporting betaENSG00000123191ATP7Bchr13:51932673-52011494:-Tbio753.925
natural cytotoxicity triggering receptor 3ENSG00000204475NCR3chr6:31588895-31592985:-Tbio178.927
lysine demethylase 3AENSG00000115548KDM3Achr2:86440647-86492716:+Tchem45.4834
kallikrein 1ENSG00000167748KLK1chr19:50819148-50823787:-Tchem224.49
nischarinENSG00000010322NISCHchr3:52455118-52493071:+Tclin227.535
cytochrome P450 family 51 subfamily A member 1ENSG00000001630CYP51A1chr7:92112151-92142952:-Tchem173.395
cholinergic receptor muscarinic 1ENSG00000168539CHRM1chr11:62908679-62921807:-Tclin322.66
solute carrier family 2 member 9ENSG00000109667SLC2A9chr4:9771153-10054936:-Tbio149.604
insulin degrading enzymeENSG00000119912IDEchr10:92451684-92574076:-Tchem438.05
gamma-glutamyltransferase 1ENSG00000100031GGT1chr22:24583750-24629005:+Tbio467.973
glucosidase alpha, acidENSG00000171298GAAchr17:80101556-80119879:+Tclin664.644
kallikrein related peptidase 10ENSG00000129451KLK10chr19:51012739-51020175:-Tbio71.9466
dual specificity phosphatase 6ENSG00000139318DUSP6chr12:89347232-89353271:-Tbio114.927
cell division cycle 14AENSG00000079335CDC14Achr1:100351734-100520277:+Tbio70.5393
ubiquitin specific peptidase 2ENSG00000036672USP2chr11:119355215-119381726:-Tbio45.3155
hyaluronidase 1ENSG00000114378HYAL1chr3:50299889-50312381:-Tbio83.4483
solute carrier family 10 member 4ENSG00000145248SLC10A4chr4:48483343-48489196:+Tbio259.39
cyclin A1ENSG00000133101CCNA1chr13:36431520-36442882:+Tbio82.79

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