PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
proprotein convertase subtilisin/kexin type 2ENSG00000125851PCSK2chr20:17226107-17484578:+Tchem125.919
ATPase family AAA domain containing 2BENSG00000119778ATAD2Bchr2:23748664-23927114:-Tchem2.32692
p21 (RAC1) activated kinase 2ENSG00000180370PAK2chr3:196739857-196832647:+Tchem126.363
ATP binding cassette subfamily A member 1ENSG00000165029ABCA1chr9:104781002-104928237:-Tclin1223.21
serine protease 3ENSG00000010438PRSS3chr9:33750466-33799231:+Tchem108.531
mannan binding lectin serine peptidase 2ENSG00000009724MASP2chr1:11026523-11047233:-Tbio177.012
insulin like growth factor binding protein 7ENSG00000163453IGFBP7chr4:57030773-57110385:-Tbio526.32
TNF receptor superfamily member 13BENSG00000240505TNFRSF13Bchr17:16929816-16972118:-Tbio159.014
complement factor BENSG00000243649CFBchr6:31945650-31952084:+Tbio324.078
nuclear receptor subfamily 2 group F member 1ENSG00000175745NR2F1chr5:93583337-93594615:+Tbio94.7741
collagen type IV alpha 6 chainENSG00000197565COL4A6chrX:108155607-108439497:-Tbio31.1022
glutamate metabotropic receptor 3ENSG00000198822GRM3chr7:86643914-86864884:+Tchem82.2836
Rho associated coiled-coil containing protein kinase 2ENSG00000134318ROCK2chr2:11179761-11348330:-Tclin179.137
ATP binding cassette subfamily A member 12ENSG00000144452ABCA12chr2:214931542-215138428:-Tbio192.591
gelsolinENSG00000148180GSNchr9:121207794-121332843:+Tbio909.383
carbonic anhydrase 1ENSG00000133742CA1chr8:85327608-85379014:-Tclin4036.28
mucin 6, oligomeric mucus/gel-formingENSG00000184956MUC6chr11:1012821-1036706:-Tbio202.996
lecithin-cholesterol acyltransferaseENSG00000213398LCATchr16:67939750-67944131:-Tbio1285.9
dual specificity phosphatase 2ENSG00000158050DUSP2chr2:96143166-96145440:-Tbio207.602
crumbs cell polarity complex component 1ENSG00000134376CRB1chr1:197268204-197478455:+Tbio119.288

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