PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
microfibril associated protein 2ENSG00000117122MFAP2chr1:16974502-16980835:-Tbio35.5312
calcium voltage-gated channel subunit alpha1 GENSG00000006283CACNA1Gchr17:50561068-50627474:+Tclin142.549
elastase, neutrophil expressedENSG00000197561ELANEchr19:851014-856247:+Tclin850.58
casein kinase 1 alpha 1ENSG00000113712CSNK1A1chr5:149492197-149551552:-Tchem73.152
ATP binding cassette subfamily A member 5ENSG00000154265ABCA5chr17:69244311-69327244:-Tbio12.5072
acetyl-CoA carboxylase alphaENSG00000278540ACACAchr17:37084988-37406818:-Tchem121.449
ATPase H+ transporting V0 subunit a2ENSG00000185344ATP6V0A2chr12:123712318-123761755:+Tbio551.542
iodothyronine deiodinase 3ENSG00000197406DIO3chr14:101561351-101563452:+Tbio180.881
presenilin 2ENSG00000143801PSEN2chr1:226870184-226896105:+Tchem370.211
muscleblind like splicing regulator 1ENSG00000152601MBNL1chr3:152243828-152465780:+Tbio244.633
phosphodiesterase 3BENSG00000152270PDE3Bchr11:14643723-14872044:+Tclin242.497
proteasome 26S subunit, ATPase 5ENSG00000087191PSMC5chr17:63827152-63832026:+Tbio36.9063
protein tyrosine phosphatase receptor type UENSG00000060656PTPRUchr1:29236516-29326813:+Tbio280.131
phospholipase D2ENSG00000129219PLD2chr17:4807096-4823434:+Tchem147.906
TNF receptor superfamily member 1AENSG00000067182TNFRSF1Achr12:6328757-6342114:-Tchem1231.49
calpain 2ENSG00000162909CAPN2chr1:223701593-223776018:+Tchem241.85
proteasome 20S subunit beta 1ENSG00000008018PSMB1chr6:170535117-170553341:-Tclin12.7612
CD14 moleculeENSG00000170458CD14chr5:140631728-140633701:-Tbio2951.77
L3MBTL histone methyl-lysine binding protein 4ENSG00000154655L3MBTL4chr18:5954706-6415237:-Tbio2.31111
complement C4A (Rodgers blood group)ENSG00000244731C4Achr6:31982024-32002681:+Tbio603.591

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