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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
jumonji domain containing 6, arginine demethylase and lysine hydroxylase	ENSG00000070495	JMJD6	chr17:76712832-76726799:-	Tbio	101.741
glutamate ionotropic receptor NMDA type subunit 1	ENSG00000176884	GRIN1	chr9:137138390-137168762:+	Tclin	752.044
solute carrier family 16 member 4	ENSG00000168679	SLC16A4	chr1:110362848-110391082:-	Tbio	48.4206
mannose receptor C-type 1	ENSG00000260314	MRC1	chr10:17809344-17911170:+	Tbio	136.664
opioid receptor kappa 1	ENSG00000082556	OPRK1	chr8:53225716-53251697:-	Tclin	692.586
fibroblast growth factor 10	ENSG00000070193	FGF10	chr5:44303544-44389706:-	Tbio	183.214
phosphatidylinositol 4-kinase alpha	ENSG00000241973	PI4KA	chr22:20707691-20859417:-	Tchem	32.3004
gamma-aminobutyric acid type B receptor subunit 2	ENSG00000136928	GABBR2	chr9:98288109-98709197:-	Tclin	119.459
WD repeat domain 1	ENSG00000071127	WDR1	chr4:10074339-10116949:-	Tbio	22.3694
Fc fragment of IgG receptor Ia	ENSG00000150337	FCGR1A	chr1:149782671-149792518:+	Tchem	1075.74
Indian hedgehog signaling molecule	ENSG00000163501	IHH	chr2:219054420-219060467:-	Tbio	59.1849
ADAMTS like 4	ENSG00000143382	ADAMTSL4	chr1:150549369-150560937:+	Tbio	24.9411
kelch like family member 38	ENSG00000175946	KLHL38	chr8:123645527-123652950:-	Tdark	0
calcium voltage-gated channel subunit alpha1 A	ENSG00000141837	CACNA1A	chr19:13206442-13623990:-	Tbio	1044.93
tenascin XB	ENSG00000168477	TNXB	chr6:32041154-32115334:-	Tbio	59.827
steroid 5 alpha-reductase 2	ENSG00000277893	SRD5A2	chr2:31522480-31581067:-	Tclin	303.054
caspase 7	ENSG00000165806	CASP7	chr10:113679162-113730907:+	Tchem	355.552
cytochrome b-245 beta chain	ENSG00000165168	CYBB	chrX:37780011-37813461:+	Tchem	631.099
farnesyl-diphosphate farnesyltransferase 1	ENSG00000079459	FDFT1	chr8:11795573-11839309:+	Tchem	70.505
insulin like 3	ENSG00000248099	INSL3	chr19:17816512-17821574:-	Tbio	196.571

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