PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
semaphorin 4DENSG00000187764SEMA4Dchr9:89360787-89498130:-Tbio155.653
adiponectin, C1Q and collagen domain containingENSG00000181092ADIPOQchr3:186842690-186858463:+Tbio6859.63
alkaline phosphatase, germ cellENSG00000163286ALPPL2chr2:232406843-232410714:+Tchem100.334
thioredoxin domain containing 5ENSG00000239264TXNDC5chr6:7881517-7910814:-Tbio35.7452
tripartite motif containing 16ENSG00000221926TRIM16chr17:15627960-15684311:-Tbio15.6514
lipase G, endothelial typeENSG00000101670LIPGchr18:49560699-49599182:+Tchem154.142
BLK proto-oncogene, Src family tyrosine kinaseENSG00000136573BLKchr8:11494001-11564604:+Tchem82.1316
glutamate ionotropic receptor kainate type subunit 2ENSG00000164418GRIK2chr6:101398788-102070083:+Tclin198.673
integrin subunit alpha LENSG00000005844ITGALchr16:30472658-30523185:+Tclin1456.66
FAT atypical cadherin 4ENSG00000196159FAT4chr4:125316399-125492932:+Tbio23.9045
lymphocyte activating 3ENSG00000089692LAG3chr12:6772512-6778455:+Tbio97.234
nuclear receptor binding SET domain protein 1ENSG00000165671NSD1chr5:177133025-177300215:+Tbio167.216
solute carrier family 44 member 4ENSG00000204385SLC44A4chr6:31863192-31879046:-Tbio16.1179
iduronate 2-sulfataseENSG00000010404IDSchrX:149476990-149521096:-Tbio1108.62
cytochrome P450 family 7 subfamily A member 1ENSG00000167910CYP7A1chr8:58490178-58500236:-Tbio359.283
lumicanENSG00000139329LUMchr12:91102629-91111831:-Tbio108.205
proteasome 20S subunit alpha 3ENSG00000100567PSMA3chr14:58244831-58272012:+Tbio15.525
adenine phosphoribosyltransferaseENSG00000198931APRTchr16:88809339-88811944:-Tbio504.67
threonyl-tRNA synthetase 1ENSG00000113407TARSchr5:33440696-33469539:+Tchem42.4095
neurotrophin 3ENSG00000185652NTF3chr12:5432112-5521536:+Tbio400.338

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