PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| calpain 10 | ENSG00000142330 | CAPN10 | chr2:240586716-240617705:+ | Tbio | 267.625 |
| ataxin 3 | ENSG00000066427 | ATXN3 | chr14:92038652-92106621:- | Tbio | 892.286 |
| interleukin 3 receptor subunit alpha | ENSG00000185291 | IL3RA | chrX:1336616-1382689:+ | Tbio | 177.32 |
| ATPase H+ transporting V0 subunit d2 | ENSG00000147614 | ATP6V0D2 | chr8:85987323-86154228:+ | Tbio | 6.23089 |
| prolyl 4-hydroxylase, transmembrane | ENSG00000178467 | P4HTM | chr3:48989886-49007154:+ | Tchem | 588.808 |
| ephrin A5 | ENSG00000184349 | EFNA5 | chr5:107376889-107670895:- | Tbio | 194.113 |
| LIM domain kinase 1 | ENSG00000106683 | LIMK1 | chr7:74082933-74122525:+ | Tchem | 148.629 |
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 | ENSG00000173473 | SMARCC1 | chr3:47585272-47782106:- | Tbio | 30.5151 |
| sodium voltage-gated channel alpha subunit 9 | ENSG00000169432 | SCN9A | chr2:166195185-166375993:- | Tclin | 313.924 |
| ATP synthase F1 subunit alpha | ENSG00000152234 | ATP5A1 | chr18:46080248-46104334:- | Tbio | 53.9453 |
| growth differentiation factor 3 | ENSG00000184344 | GDF3 | chr12:7689782-7695776:- | Tbio | 58.8018 |
| kallikrein related peptidase 7 | ENSG00000169035 | KLK7 | chr19:50976482-50984099:- | Tchem | 102.412 |
| proteasome 20S subunit alpha 1 | ENSG00000129084 | PSMA1 | chr11:14504874-14643635:- | Tclin | 15.4233 |
| 3-hydroxy-3-methylglutaryl-CoA synthase 1 | ENSG00000112972 | HMGCS1 | chr5:43289395-43313512:- | Tbio | 17.8397 |
| cystatin SN | ENSG00000170373 | CST1 | chr20:23747553-23751268:- | Tbio | 40.5733 |
| cell adhesion molecule L1 like | ENSG00000134121 | CHL1 | chr3:196596-409417:+ | Tbio | 80.391 |
| death associated protein kinase 3 | ENSG00000167657 | DAPK3 | chr19:3958453-3971123:- | Tchem | 692.658 |
| secretoglobin family 1A member 1 | ENSG00000149021 | SCGB1A1 | chr11:62405103-62423195:+ | Tbio | 472.911 |
| solute carrier family 1 member 3 | ENSG00000079215 | SLC1A3 | chr5:36606355-36688334:+ | Tchem | 247.771 |
| neurotrimin | ENSG00000182667 | NTM | chr11:131370478-132336822:+ | Tbio | 73.6194 |
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