PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
kininogen 1ENSG00000113889KNG1chr3:186717276-186743954:+Tchem4883.73
solute carrier organic anion transporter family member 1B3ENSG00000111700SLCO1B3chr12:20810702-20916911:+Tchem213.557
protein tyrosine phosphatase non-receptor type 6ENSG00000111679PTPN6chr12:6946468-6961316:+Tchem429.513
peptidase inhibitor 15ENSG00000137558PI15chr8:74824537-74855029:+Tbio7.49964
caspase 1ENSG00000137752CASP1chr11:105025443-105035250:-Tchem917.746
FUS RNA binding proteinENSG00000089280FUSchr16:31180110-31194871:+Tbio626.969
surfactant protein DENSG00000133661SFTPDchr10:79937740-79982614:-Tbio533.095
uncoupling protein 2ENSG00000175567UCP2chr11:73974667-73983307:-Tbio597.073
phosphatidylethanolamine binding protein 1ENSG00000089220PEBP1chr12:118135858-118145584:+Tbio383.421
actinin alpha 4ENSG00000130402ACTN4chr19:38647649-38731583:+Tbio460.224
nucleotide binding oligomerization domain containing 1ENSG00000106100NOD1chr7:30424527-30478784:-Tchem216.136
solute carrier family 34 member 2ENSG00000157765SLC34A2chr4:25655301-25678748:+Tbio71.5988
lysine demethylase 4DENSG00000186280KDM4Dchr11:94973681-94999518:+Tchem11.8333
insulin like growth factor binding protein 5ENSG00000115461IGFBP5chr2:216672105-216695525:-Tchem241.575
fms related receptor tyrosine kinase 3 ligandENSG00000090554FLT3LGchr19:49474207-49486231:+Tbio261.148
ATPase H+ transporting V0 subunit a4ENSG00000105929ATP6V0A4chr7:138706295-138799560:-Tbio28
toll like receptor 7ENSG00000196664TLR7chrX:12867083-12890380:+Tclin545.05
mitogen-activated protein kinase 8ENSG00000107643MAPK8chr10:48306639-48439360:+Tchem2545.41
surfactant protein A2ENSG00000185303SFTPA2chr10:79555852-79560397:-Tbio2174.95
protoporphyrinogen oxidaseENSG00000143224PPOXchr1:161166410-161178013:+Tchem860.467

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