PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
5-hydroxytryptamine receptor 3AENSG00000166736HTR3Achr11:113974881-113990313:+Tclin283.539
C-X-C motif chemokine ligand 14ENSG00000145824CXCL14chr5:135570679-135579279:-Tbio86.7635
potassium inwardly rectifying channel subfamily J member 10ENSG00000177807KCNJ10chr1:160037467-160070248:-Tbio128.008
filamin AENSG00000196924FLNAchrX:154348524-154374638:-Tbio449.246
heparin binding EGF like growth factorENSG00000113070HBEGFchr5:140332843-140346631:-Tbio442.104
solute carrier family 1 member 2ENSG00000110436SLC1A2chr11:35251206-35420063:-Tchem406.463
secreted frizzled related protein 5ENSG00000120057SFRP5chr10:97766751-97771952:-Tbio51.45
ubiquitin specific peptidase 14ENSG00000101557USP14chr18:158383-214629:+Tbio45.9583
phosphate regulating endopeptidase homolog X-linkedENSG00000102174PHEXchrX:22032441-22251310:+Tbio238.567
Fc fragment of IgE receptor IaENSG00000179639FCER1Achr1:159289714-159308224:+Tbio640.352
complement factor IENSG00000205403CFIchr4:109740694-109802179:-Tbio377.272
ATP binding cassette subfamily B member 5ENSG00000004846ABCB5chr7:20615207-20777038:+Tbio51.3051
CXADR Ig-like cell adhesion moleculeENSG00000154639CXADRchr21:17512382-17593579:+Tbio393.598
BCL2 like 2ENSG00000129473BCL2L2chr14:23298790-23311759:+Tchem107.829
calcium/calmodulin dependent protein kinase II gammaENSG00000148660CAMK2Gchr10:73812501-73874591:-Tchem788.477
myelin protein zeroENSG00000158887MPZchr1:161304735-161309972:-Tbio432.775
cannabinoid receptor 1ENSG00000118432CNR1chr6:88139864-88166359:-Tclin2005.16
metastasis associated 1 family member 2ENSG00000149480MTA2chr11:62593214-62601840:-Tbio397.938
acid sensing ion channel subunit 1ENSG00000110881ASIC1chr12:50057548-50083611:+Tchem255.174
derlin 1ENSG00000136986DERL1chr8:123013164-123042423:-Tbio74.0095

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