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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
neuromedin B	ENSG00000197696	NMB	chr15:84655129-84658563:-	Tbio	139.679
prolactin	ENSG00000172179	PRL	chr6:22287244-22297501:-	Tbio	9150.32
casein kinase 2 beta	ENSG00000204435	CSNK2B	chr6:31665236-31670343:+	Tbio	343.988
integrin subunit alpha X	ENSG00000140678	ITGAX	chr16:31355134-31382997:+	Tbio	583.957
cyclin dependent kinase 5 regulatory subunit 1	ENSG00000176749	CDK5R1	chr17:32486619-32491256:+	Tchem	206.44
cyclin dependent kinase 11B	ENSG00000248333	CDK11B	chr1:1635227-1722818:-	Tchem	102.056
CD109 molecule	ENSG00000156535	CD109	chr6:73695785-73828316:+	Tbio	56.3339
ATPase H+ transporting V1 subunit C1	ENSG00000155097	ATP6V1C1	chr8:103021063-103073051:+	Tbio	12.4682
C-C motif chemokine ligand 28	ENSG00000151882	CCL28	chr5:43376645-43412391:-	Tbio	321.556
thiosulfate sulfurtransferase	ENSG00000128311	TST	chr22:37010859-37020183:-	Tbio	223.475
heparanase	ENSG00000173083	HPSE	chr4:83292461-83335153:-	Tchem	619.791
potassium calcium-activated channel subfamily N member 4	ENSG00000104783	KCNN4	chr19:43766533-43781257:-	Tchem	272.234
KIT ligand	ENSG00000049130	KITLG	chr12:88492793-88580851:-	Tbio	1924.84
AFG3 like matrix AAA peptidase subunit 2	ENSG00000141385	AFG3L2	chr18:12328944-12377314:-	Tbio	30.7411
phosphoenolpyruvate carboxykinase 1	ENSG00000124253	PCK1	chr20:57561080-57568112:+	Tbio	483.378
retinoid X receptor gamma	ENSG00000143171	RXRG	chr1:165400917-165445355:-	Tclin	30.653
solute carrier family 5 member 5	ENSG00000105641	SLC5A5	chr19:17871973-17895174:+	Tbio	413.872
peptidylprolyl isomerase E	ENSG00000084072	PPIE	chr1:39692182-39763914:+	Tbio	24.1639
sushi repeat containing protein X-linked 2	ENSG00000102359	SRPX2	chrX:100644218-100671299:+	Tbio	42.3136
glucose-6-phosphatase catalytic subunit	ENSG00000131482	G6PC	chr17:42900797-42913369:+	Tchem	317.569

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