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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
major histocompatibility complex, class I-related	ENSG00000153029	MR1	chr1:181033425-181061938:+	Tbio	138.102
joining chain of multimeric IgA and IgM	ENSG00000132465	JCHAIN	chr4:70655541-70681817:-	Tbio	222.353
cathepsin L	ENSG00000135047	CTSL	chr9:87725519-87731393:+	Tchem	678.305
C-C motif chemokine receptor 4	ENSG00000183813	CCR4	chr3:32951574-32956349:+	Tclin	313.888
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	ENSG00000133056	PIK3C2B	chr1:204422628-204494724:-	Tchem	28.558
phospholipase A2 group IID	ENSG00000117215	PLA2G2D	chr1:20111939-20119566:-	Tchem	68.8075
protein kinase C delta	ENSG00000163932	PRKCD	chr3:53156009-53192717:+	Tclin	1972.93
isoleucyl-tRNA synthetase 2, mitochondrial	ENSG00000067704	IARS2	chr1:220094102-220148041:+	Tbio	8.44329
thrombopoietin	ENSG00000090534	THPO	chr3:184371935-184378144:-	Tbio	917.354
glypican 1	ENSG00000063660	GPC1	chr2:240435671-240468078:+	Tbio	104.35
alpha-2-glycoprotein 1, zinc-binding	ENSG00000160862	AZGP1	chr7:99966720-99976157:-	Tbio	192.718
histone deacetylase 7	ENSG00000061273	HDAC7	chr12:47782722-47833132:-	Tclin	75.3032
potassium two pore domain channel subfamily K member 2	ENSG00000082482	KCNK2	chr1:215005775-215237093:+	Tclin	279.057
trefoil factor 2	ENSG00000160181	TFF2	chr21:42346357-42351128:-	Tbio	139.695
phosphodiesterase 8B	ENSG00000113231	PDE8B	chr5:77210449-77429807:+	Tclin	46.7845
occludin	ENSG00000197822	OCLN	chr5:69492292-69558104:+	Tbio	92.2595
cystatin B	ENSG00000160213	CSTB	chr21:43772512-43776445:-	Tbio	364.061
TNF receptor superfamily member 10c	ENSG00000173535	TNFRSF10C	chr8:23084355-23117437:+	Tbio	87.3203
major facilitator superfamily domain containing 12	ENSG00000161091	MFSD12	chr19:3538261-3574290:-	Tdark	2
HtrA serine peptidase 2	ENSG00000115317	HTRA2	chr2:74529377-74533348:+	Tbio	176.554

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